CAJ | 학술논문

背景：脑血管畸形是在青壮年人群中造成出血性脑卒中的常见病因，畸形血管破裂出血可引发严重的神经功能障碍。脑血管畸形的形成及发病原理尚不明确。现代分子生物学的研究表明血管生长相关因子在脑血管畸形中可能存在异常表达。 　　目的：评价血管生长相关因子在脑畸形血管中的表达差异，探讨血管生长相关因子与脑畸形血管形成的关系。方法：选择脑血管畸形患者与颅内出血开颅治疗患者各50例，通过免疫组织化学染色方法检测脑血管畸形标本和开颅治疗患者颞浅动脉标本中血管因子的表达差异。 　　结果与结论：正常颞浅动脉中血管生长相关因子(血管内皮生长因子和转化生长因子α)几乎不表达，畸形血管中两者高表达(P<0.05)。结果证实，与正常血管相比，脑血管畸形患者血管内皮生长因子和转化生长因子α的表达存在明显差异，脑畸形血管患者血管组织可表达更多的血管内皮生长因子和转化生长因子α。
배경：뇌혈관기형시재청장년인군중조성출혈성뇌졸중적상견병인，기형혈관파렬출혈가인발엄중적신경공능장애。뇌혈관기형적형성급발병원리상불명학。현대분자생물학적연구표명혈관생장상관인자재뇌혈관기형중가능존재이상표체。 　　목적：평개혈관생장상관인자재뇌기형혈관중적표체차이，탐토혈관생장상관인자여뇌기형혈관형성적관계。방법：선택뇌혈관기형환자여로내출혈개로치료환자각50례，통과면역조직화학염색방법검측뇌혈관기형표본화개로치료환자섭천동맥표본중혈관인자적표체차이。 　　결과여결론：정상섭천동맥중혈관생장상관인자(혈관내피생장인자화전화생장인자α)궤호불표체，기형혈관중량자고표체(P<0.05)。결과증실，여정상혈관상비，뇌혈관기형환자혈관내피생장인자화전화생장인자α적표체존재명현차이，뇌기형혈관환자혈관조직가표체경다적혈관내피생장인자화전화생장인자α。
BACKGROUND:Cerebral vascular malformations are the leading cause of hemorrhagic apoplexy in young adults, and the rupture and bleeding of malformed vessels may cause severe neurological dysfunction. The mechanism of cerebral vascular malformations remains unclear. Modern molecular biology studies have shown that, angiogenic growth factors are abnormal y expressed in cerebral vascular malformations. OBJECTIVE:To evaluate differences in the expression of angiogenic growth factors in cerebral vascular malformations, and discuss the possible relationship between cerebral vascular malformations and angiogenic growth factors. METHODS:Fifty patients with cerebral vascular malformations and fifty patients with intracerebral hemorrhage were included in this study. The expressions of angiogenic growth factor (vascular endothelial growth factor and transforming growth factor-α) in the cerebral vascular malformation specimens and the normal superficial temporal artery specimens were detected with immunohistochemical staining. RESULTS AND CONCLUSION:In the normal superficial temporal artery of intracerebral hemorrhage patients, no expression of vascular endothelial growth factor and transforming growth factor-αwas found;in the vascular malformations, they were highly expressed (P<0.05). Compared with normal blood vessels, vascular endothelial growth factor and transforming growth factor-αexpression was significantly increased in patients with cerebral vascular malformations.