CAJ | 학술논문

背景：近年来多孔材料体内植入的基础研究和临床应用均展示了良好的应用前景。目的：回顾近10年来组织工程多孔材料的基础与临床研究进展，总结存在的问题并展望未来。方法：由作者检索 PubMed 数据库和中国知网数据库获得文献，英文检索词为 porous material, bone implantation”，中文检索词为“多孔材料，骨移植”。纳入用于体内外及临床研究的多孔材料及其复合材料，以及与骨缺损修复或骨组织工程密切相关的多孔材料。结果与结论：目前研究较多的多孔材料有羟基磷灰石、钛及其合金、聚乙烯、磷酸钙类等，从大量的体内外实验结果来看，多孔材料展示了其良好的组织相容性和骨诱导特性，但有利于组织最快和最有效长入的孔隙尺寸尚无统一的标准，不规则异形多孔材料的孔隙率怎样获得和控制，材料的弹性模量如何调控，以及如何获得材料100%的有效孔隙率等问题尚未有明确的标准答案，另外临床应用过程中发生的炎症和暴露等并发症的问题是否与前述问题相关还无法确定。
배경：근년래다공재료체내식입적기출연구화림상응용균전시료량호적응용전경。목적：회고근10년래조직공정다공재료적기출여림상연구진전，총결존재적문제병전망미래。방법：유작자검색 PubMed 수거고화중국지망수거고획득문헌，영문검색사위 porous material, bone implantation”，중문검색사위“다공재료，골이식”。납입용우체내외급림상연구적다공재료급기복합재료，이급여골결손수복혹골조직공정밀절상관적다공재료。결과여결론：목전연구교다적다공재료유간기린회석、태급기합금、취을희、린산개류등，종대량적체내외실험결과래간，다공재료전시료기량호적조직상용성화골유도특성，단유리우조직최쾌화최유효장입적공극척촌상무통일적표준，불규칙이형다공재료적공극솔즘양획득화공제，재료적탄성모량여하조공，이급여하획득재료100%적유효공극솔등문제상미유명학적표준답안，령외림상응용과정중발생적염증화폭로등병발증적문제시부여전술문제상관환무법학정。
BACKGROUND:A favorable application prospect has been showed in basic and clinical research of porous material implantation in recent years. OBJECTIVE:To retrospect the progress in basic and clinical research of porous materials in the past 10 years and to summarize the existing problems and clinical prospects. METHODS:A computer-based search of PubMed and CNKI databases was performed for relevant articles using the keywords of“porous material, bone implantation”in English and Chinese, respectively. The included articles were related to porous materials and composite materials used in vitro, in vivo or in clinic, as wel as porous materials closely related with bone defect repair or bone tissue engineering. RESULTS AND CONCLUSION:Hydroxyapatite, titamium and its al oys, polyethylene, calcium phosphates are porous materials that have been studied presently. Increasing experimental studies have shown that the porous materials have good histocompatibility and osteoinductive features in vitro and in vivo. But the uniform standards for porosity size in favor of tissue growth that is fastest and most effective have not been obtained. It is unclear how to gain and control the porosity of porous materials that are irregular, how to control the elasticity modulus, and how to gain 100%porosity effectively. Furthermore, whether the inflammation and exposure of porous materials in clinical application are related to the above-mentioned problems are unable to confirm.