CAJ | 학술논문

背景：随着社会经济的发展和老龄化的加剧，冠状动脉性心脏病成为危害人类生命健康的首要致死病因，与此同时，心血管介入治疗(尤其是支架植入)在当今心血管疾病治疗中的地位与日俱增。目的：阐述心脏介入材料的发展历程、研究进展以及最新临床应用试验，可降解支架的优点以及弊端，同时展望其未来的发展趋势和改进方向。方法：应用计算机检索 PubMed 数据库1999年1月至2014年4月间相关文献，检索词为“stent, scaffold, bioabsorbable, bioresorbable, biodegradable, biocompatibility, material properties”，并限定文章语言种类为英语，对资料进行初审。结果与结论：新型完全生物可降解支架是心脏介入治疗中的又一重大进展，为冠状动脉性心脏病患者带来新的福音。在植入初始阶段表现出与金属裸支架相同的机械支撑力，植入后释放抗增殖药物，预防血栓形成及再狭窄，同时在特定的时间内完全降解，明显减少了晚期及极晚期血栓形成及支架内再狭窄的风险。但可降解支架的长期安全性及有效性有待进一步研究来证明。支架设计及材料学革新是克服当前可降解支架缺点研究与应用的重点。
배경：수착사회경제적발전화노령화적가극，관상동맥성심장병성위위해인류생명건강적수요치사병인，여차동시，심혈관개입치료(우기시지가식입)재당금심혈관질병치료중적지위여일구증。목적：천술심장개입재료적발전역정、연구진전이급최신림상응용시험，가강해지가적우점이급폐단，동시전망기미래적발전추세화개진방향。방법：응용계산궤검색 PubMed 수거고1999년1월지2014년4월간상관문헌，검색사위“stent, scaffold, bioabsorbable, bioresorbable, biodegradable, biocompatibility, material properties”，병한정문장어언충류위영어，대자료진행초심。결과여결론：신형완전생물가강해지가시심장개입치료중적우일중대진전，위관상동맥성심장병환자대래신적복음。재식입초시계단표현출여금속라지가상동적궤계지탱력，식입후석방항증식약물，예방혈전형성급재협착，동시재특정적시간내완전강해，명현감소료만기급겁만기혈전형성급지가내재협착적풍험。단가강해지가적장기안전성급유효성유대진일보연구래증명。지가설계급재료학혁신시극복당전가강해지가결점연구여응용적중점。
BACKGROUND:With the social and economic development and aging, coronary heart disease has become the primary cause of death endangering human life and health, while cardiovascular intervention (especial y stenting) in the treatment of cardiovascular disease is at a growing status. OBJECTIVE:To describe the development, research progress and latest clinical application of heart interventional materials as wel as advantages and disadvantages of biodegradable stents, and meanwhile to prospect for its future development and improvement. METHODS:A computer-based online search was conducted in PubMed for English language publications from January 1999 to April 2014 using the key words of“stent, scaffold, bioabsorbable, bioresorbable, biodegradable, biocompatibility, material properties”in English. RESULTS AND CONCLUSION:The new ful y biodegradable stents are considered as another major progress in the cardiac intervention, which brings a new gospel for patients with coronary heart disease. In the initial stage of implantation, biodegradable stents exhibit the same mechanical support as bare metal stents;after implantation, anti-proliferative drugs are released to prevent thrombosis and restenosis, and the stent is completely degraded within a specified period, which significantly reduces the late-stage and very late-stage thrombosis and the risk of in-stent restenosis. However, long-term safety and efficacy of biodegradable stents need further studies. Innovation of stent design and materials science is the key to overcome the current shortcomings of biodegradable stents.