CAJ | 학술논문

目的探讨托特罗定联合氟哌噻吨美利曲辛治疗女性膀胱过度活动症(OAB)的临床疗效及安全性.方法选择确诊为女性膀胱过度活动症患者84例,采用随机数字表法分为观察组和对照组各42例.观察组42例采用托特罗定联合氟哌噻吨美利曲辛治疗,对照组42例单用托特罗定治疗,4周后记录并比较两组临床疗效.结果观察组总有效率明显优于对照组(95.24％比76.19％,x2=6.291,P＜0.05)；两组平均24h排尿次数、平均24 h尿失禁次数、初始尿意容量及最大膀胱压容量差异均有统计学意义(均P＜0.05).结论托特罗定联合氟哌噻吨美利曲辛治疗女性膀胱过度活动症具有疗程短、疗效高、不良反应少等优点.
목적 탐토탁특라정연합불고새둔미리곡신치료녀성방광과도활동증(OAB)적림상료효급안전성.방법 선택학진위녀성방광과도활동증환자84례,채용수궤수자표법분위관찰조화대조조각42례.관찰조42례채용탁특라정연합불고새둔미리곡신치료,대조조42례단용탁특라정치료,4주후기록병비교량조림상료효.결과 관찰조총유효솔명현우우대조조(95.24％비76.19％,x2=6.291,P＜0.05)；량조평균24h배뇨차수、평균24 h뇨실금차수、초시뇨의용량급최대방광압용량차이균유통계학의의(균P＜0.05).결론 탁특라정연합불고새둔미리곡신치료녀성방광과도활동증구유료정단、료효고、불량반응소등우점.
Objective To investigate the clinical efficacy and safety of tolterodine combined with flupentixol melitracen in the treatment of women with overactive bladder (OAB).Methods 84 female patients with OAB were chosen and randomly divided into the observation group and the control group.42 cases in observation group were treated with tolterodine combined with flupentixol melitracen.42 cases in control group were only treated with tolterodine.The clinical efficacy was recorded and compared after treatment for 4 weeks.Results The total effective rate of the observation group was higher than the control group (95.24％ vs 76.19％,x2 =6.291,P ＜ 0.05).The 24h frequency of urination,the average 24h number of incontinence episodes,initial urinate capacity and maximum bladder pressure capacity had statistically significant differences between the two groups (all P ＜ 0.05).Conclusion Tolterodine combined with flupentixol melitracen in the treatment of women with OAB has advantages of short course of treatment,excellent efficacy,and few side effects.