中华脑科疾病与康复杂志（电子版）
中華腦科疾病與康複雜誌（電子版）
중화뇌과질병여강복잡지（전자판）
CHINESE JOURNAL OF BRAIN DI8SEASES AND REHABILITATIN(ELECTRONIC EDITION)
2014年
3期
45-48
,共4页
趋化因子CXCL12%受体,CXCR4%卒中%机制
趨化因子CXCL12%受體,CXCR4%卒中%機製
추화인자CXCL12%수체,CXCR4%졸중%궤제
Chemokine CXCL12%Receptors,CXCR4%Stroke%Mechanism
趋化因子CXCL12及其受体CXCR4参与炎症反应、诱导细胞迁徙和归巢等多种生理和病理过程，且与神经的产生、内分泌及变性等均密切相关。动物实验及临床研究证明，CXCL12及其传导通路在缺血性脑卒中不同时期具有加重损伤及促进功能重建的双重作用，有可能成为预测缺血性脑卒中近期发作及预后的一个新的生物学指标，为脑卒中预防及治疗开创新的途径。
趨化因子CXCL12及其受體CXCR4參與炎癥反應、誘導細胞遷徙和歸巢等多種生理和病理過程，且與神經的產生、內分泌及變性等均密切相關。動物實驗及臨床研究證明，CXCL12及其傳導通路在缺血性腦卒中不同時期具有加重損傷及促進功能重建的雙重作用，有可能成為預測缺血性腦卒中近期髮作及預後的一箇新的生物學指標，為腦卒中預防及治療開創新的途徑。
추화인자CXCL12급기수체CXCR4삼여염증반응、유도세포천사화귀소등다충생리화병리과정，차여신경적산생、내분비급변성등균밀절상관。동물실험급림상연구증명，CXCL12급기전도통로재결혈성뇌졸중불동시기구유가중손상급촉진공능중건적쌍중작용，유가능성위예측결혈성뇌졸중근기발작급예후적일개신적생물학지표，위뇌졸중예방급치료개창신적도경。
Chemokine CXCL12 and its receptors are participated various pathological and physiological processes , such as participated in the inflammatory response and induced cell migration and homing,etc.Moreover,CXCL12 are closely related to the generation ,endocrine and degeneration of neural system,etc.Animal experiments and clinical studies have demonstrated that CXCL 12 and its pathway have aggravated the injury and promotes reconstruction in the dual role of different periods of ischemic stroke ,there is likely to be a new biology indicator to predict recent onset and prognosis of ischemic stroke , and to inaugurate a new way for prevention and treatment of stroke .
