CAJ | 학술논문

目的：探讨无症状高尿酸血症患者血尿酸水平与颈动脉斑块数量的关系。方法选择2009年1月至2013年12月间在广东省惠州市惠阳三和医院进行健康查体人员72例，依据入选对象血尿酸水平分为高尿酸组（n=39）与正常尿酸组（n=33），随访5年血尿酸水平变化，并检测颈动脉斑块数量，对血尿酸水平与颈动脉斑块数量进行相关性分析。结果纳入患者5年随访期间，高尿酸组与正常尿酸组中男性人群血尿酸水平均高于女性人群，差异均有统计学意义（P＜0.05）。高尿酸组男性及女性血尿酸水平均高于正常尿酸组男性及女性尿酸水平，差异均有统计学意义（P＜0.05）。两组人群5年随访期间男性及女性血尿酸水平变化不明显，年度之间血尿酸水平无统计学差异（P＞0.05）。高尿酸组男性和女性颈动脉斑块数量平均为（1.9±0.5）个、（1.2±0.3）个，正常尿酸组男性和女性颈动脉斑块数量平均为（0.8±0.3）个、（0.4±0.2）个；高尿酸组男性和女性颈动脉斑块数量显著高于正常尿酸组，差异有统计学意义（P＜0.05）。颈动脉斑块数量与血尿酸水平呈正相关，男性r=0.768，女性r=0.721，均有统计学意义（P＜0.05）。结论血尿酸水平升高与颈动脉斑块增加明显正相关。
목적：탐토무증상고뇨산혈증환자혈뇨산수평여경동맥반괴수량적관계。방법선택2009년1월지2013년12월간재광동성혜주시혜양삼화의원진행건강사체인원72례，의거입선대상혈뇨산수평분위고뇨산조（n=39）여정상뇨산조（n=33），수방5년혈뇨산수평변화，병검측경동맥반괴수량，대혈뇨산수평여경동맥반괴수량진행상관성분석。결과납입환자5년수방기간，고뇨산조여정상뇨산조중남성인군혈뇨산수평균고우녀성인군，차이균유통계학의의（P＜0.05）。고뇨산조남성급녀성혈뇨산수평균고우정상뇨산조남성급녀성뇨산수평，차이균유통계학의의（P＜0.05）。량조인군5년수방기간남성급녀성혈뇨산수평변화불명현，년도지간혈뇨산수평무통계학차이（P＞0.05）。고뇨산조남성화녀성경동맥반괴수량평균위（1.9±0.5）개、（1.2±0.3）개，정상뇨산조남성화녀성경동맥반괴수량평균위（0.8±0.3）개、（0.4±0.2）개；고뇨산조남성화녀성경동맥반괴수량현저고우정상뇨산조，차이유통계학의의（P＜0.05）。경동맥반괴수량여혈뇨산수평정정상관，남성r=0.768，녀성r=0.721，균유통계학의의（P＜0.05）。결론혈뇨산수평승고여경동맥반괴증가명현정상관。
Objective To investigate the relationship between level of blood uric acid (BUA) and number of carotid plaques in patients with asymptomatic hyperuricemia. Methods The health persons (n=72) with physical examinations were chosen from the Huiyang Sanhe Hospital of Huizhou City of Guangdong Province from Jan. 2009 to Dec. 2013, and divided into high-BUA group (n=39) and normal-BUA group (n=33) according to their BUA level. The changes of BUA level were followed up for 5 years, and number of carotid plaques was detected. A correlation analysis on relationship between BUA level and number of carotid plaques was carried out. Results During 5-year follow-up period, BUA level was higher in the male than that in the female in 2 groups (P<0.05). BUA level was higher in the male and female in high-BUA group than that in the male and female in normal-BUA group (P<0.05). The changes of BUS level were not significant in the male and female in 2 groups during 5-year follow-up period, and there was no statistical difference in BUA level among different years (P>0.05). The number of carotid plaques was (1.9±0.5) averagely in the male and (1.2±0.3) in the female in high-BUA group, and (0.8±0.3) averagely in the male and (0.4±0.2) in the female in normal-BUA group (P<0.05). The number of carotid plaques was positively correlated to BUA level, and r=0.768 in the male and r=0.721 in the female (P<0.05). Conclusion The increase of BUA level is significantly correlated to the increase of number of carotid plaques.