中国循证心血管医学杂志
中國循證心血管醫學雜誌
중국순증심혈관의학잡지
CHINESE JOURNAL OF EVIDENCE-BASES CARDIOVASCULAR MEDICINE
2014年
3期
314-316
,共3页
肥厚型心肌病%益气复脉注射液%灯盏花注射液
肥厚型心肌病%益氣複脈註射液%燈盞花註射液
비후형심기병%익기복맥주사액%등잔화주사액
Hypertrophic obstructive cardiomyopathy%Yiqi Fumai Injection%Dengzhanhua Injection
目的:观察益气复脉注射液对肥厚型梗阻性心肌病(HOCM)患者的临床疗效。方法纳入34例HOCM患者,随机分为观察组(n=16)和对照组(n=18例),观察组给予益气复脉注射液治疗,对照组给予灯盏花注射液治疗,疗程为28天。比较两组患者的临床疗效及治疗前、后超声心动图参数变化情况。结果观察组和对照组的临床总有效率分别为:81.3%和27.8%,两组患者治疗后总有效率有显著统计学差异(P<0.01)。观察组患者治疗前、后心脏室间隔厚度(VS)、左室后壁厚度(LVPWT)、左室舒张末期内径(LVDED)、左室收缩末期内径(LVSED)、主动脉根部内径(AOD)、左室射血分数(LVEF)、心排出量(CO)水平比较,无统计学差异(P>0.05)。观察组患者治疗前、后二尖瓣前叶前向运动分级(SAM分级)、左室流出道(LVOT)流速、二尖瓣舒张期A峰、E峰、左室等容舒张时间(IVRT)、左室舒张高峰充盈率(LVDPFR)、左室舒张高峰充盈时间(LVDPFT)水平比较,有显著统计学差异(P<0.05),与对照组上述指标比较亦有统计学差异(P<0.05)。对照组患者治疗前后上述指比较,均无无统计学差异(P>0.05)。结论益气复脉注射液可改善HOCM舒张功能和降低左室流出道压力阶差,减低左室流出道梗阻,近期疗效满意。
目的:觀察益氣複脈註射液對肥厚型梗阻性心肌病(HOCM)患者的臨床療效。方法納入34例HOCM患者,隨機分為觀察組(n=16)和對照組(n=18例),觀察組給予益氣複脈註射液治療,對照組給予燈盞花註射液治療,療程為28天。比較兩組患者的臨床療效及治療前、後超聲心動圖參數變化情況。結果觀察組和對照組的臨床總有效率分彆為:81.3%和27.8%,兩組患者治療後總有效率有顯著統計學差異(P<0.01)。觀察組患者治療前、後心髒室間隔厚度(VS)、左室後壁厚度(LVPWT)、左室舒張末期內徑(LVDED)、左室收縮末期內徑(LVSED)、主動脈根部內徑(AOD)、左室射血分數(LVEF)、心排齣量(CO)水平比較,無統計學差異(P>0.05)。觀察組患者治療前、後二尖瓣前葉前嚮運動分級(SAM分級)、左室流齣道(LVOT)流速、二尖瓣舒張期A峰、E峰、左室等容舒張時間(IVRT)、左室舒張高峰充盈率(LVDPFR)、左室舒張高峰充盈時間(LVDPFT)水平比較,有顯著統計學差異(P<0.05),與對照組上述指標比較亦有統計學差異(P<0.05)。對照組患者治療前後上述指比較,均無無統計學差異(P>0.05)。結論益氣複脈註射液可改善HOCM舒張功能和降低左室流齣道壓力階差,減低左室流齣道梗阻,近期療效滿意。
목적:관찰익기복맥주사액대비후형경조성심기병(HOCM)환자적림상료효。방법납입34례HOCM환자,수궤분위관찰조(n=16)화대조조(n=18례),관찰조급여익기복맥주사액치료,대조조급여등잔화주사액치료,료정위28천。비교량조환자적림상료효급치료전、후초성심동도삼수변화정황。결과관찰조화대조조적림상총유효솔분별위:81.3%화27.8%,량조환자치료후총유효솔유현저통계학차이(P<0.01)。관찰조환자치료전、후심장실간격후도(VS)、좌실후벽후도(LVPWT)、좌실서장말기내경(LVDED)、좌실수축말기내경(LVSED)、주동맥근부내경(AOD)、좌실사혈분수(LVEF)、심배출량(CO)수평비교,무통계학차이(P>0.05)。관찰조환자치료전、후이첨판전협전향운동분급(SAM분급)、좌실류출도(LVOT)류속、이첨판서장기A봉、E봉、좌실등용서장시간(IVRT)、좌실서장고봉충영솔(LVDPFR)、좌실서장고봉충영시간(LVDPFT)수평비교,유현저통계학차이(P<0.05),여대조조상술지표비교역유통계학차이(P<0.05)。대조조환자치료전후상술지비교,균무무통계학차이(P>0.05)。결론익기복맥주사액가개선HOCM서장공능화강저좌실류출도압력계차,감저좌실류출도경조,근기료효만의。
Objective To observe the clinical efficacy of Yiqi Fumai Injection on hypertrophic obstructive cardiomyopathy (HOCM). Methods The patients with HOCM (n=34) were randomly divided into observation group (n=16) treated with Yiqi Fumai Injection, and control group (n=18) treated with Dengzhanhua Injection all for 28 d. The clinical efficacy and changes of echocardiogram parameters were compared between 2 groups before and after treatment. Results The total effective rate was 81.3%in observation group and 27.8%in control group (P<0.01). In observation group, interventricular septal thickness (VS), left ventricular posterior wall thickness (LVPWT), LVDED, LVSED, aortic root dimension (AOD), LVEF and cardiac output (CO) had no statistical difference before and after treatment (P>0.05), and SAM grading, velocity of left ventricular outflow tract (LVOT), mitral diastolic peak A and peak E, IVRT, LVDPFR and LVDPFT had significant and statistical difference before and after treatment (P<0.05). The comparison in all above indexes had statistical difference between 2 groups (P<0.05). In control group, all above indexes had no statistical difference before and after treatment (P>0.05). Conclusion Yiqi Fumai Injection can improve the diastolic function of HOCM, reduce LVOGT and relieve LVOTO with good short-term curative effect.