中国循证心血管医学杂志
中國循證心血管醫學雜誌
중국순증심혈관의학잡지
CHINESE JOURNAL OF EVIDENCE-BASES CARDIOVASCULAR MEDICINE
2014年
3期
308-310
,共3页
刘宏%庞兴学%王媛%纪冬梅
劉宏%龐興學%王媛%紀鼕梅
류굉%방흥학%왕원%기동매
N端脑钠肽前体%脂蛋白(a)%冠状动脉疾病
N耑腦鈉肽前體%脂蛋白(a)%冠狀動脈疾病
N단뇌납태전체%지단백(a)%관상동맥질병
N-terminal pro brain natriuretic peptide%lipoprotein (a)%coronary artery disease
目的：探讨老年冠心病患者N端脑钠肽前体（NT-proBNP）、脂蛋白（a）[LP（a）]水平与冠状动脉病变程度之间的关系。方法入选2011年1月～2012年12月在北京老年医院心内科住院并行冠状动脉造影检查的老年患者213例，根据冠状动脉造影结果分为非冠心病组（n=60），冠状动脉单支病变组（n=42），双支病变组（n=48），三支病变组（n=63）。测定四组患者空腹血清NT-proBNP、LP （a）水平并进行比较，分析NT-proBNP、LP（a）水平与冠心病患者冠状动脉病变严重程度的关系。结果随着病变支数的增多，血浆NT-proBNP及LP（a）水平有逐渐增高的趋势。冠状动脉单支病变组、双支病变组和三支病变组患者血浆NT-proBNP及LP（a）水平均高于非冠心病组，差异有统计学意义（P＜0.05）。冠状动脉单支病变组与三支病变组NT-proBNP及LP（a）水平有统计学差异（P＜0.05），而单支病变组与双支病变组，双支病变组与三支病变组间NT-proBNP及LP（a）水平比较无统计学差异（P＞0.05）。Gensini评分与NT-proBNP、LP（a）均呈明显正相关，相关系数分别为0.580、0.406，有显著统计学意义（P＜0.01）。结论 NT-proBNP、Lp（a）水平与冠状动脉病变的严重程度密切相关，对高NT-proBNP、LP（a）的患者应给予高度重视，尽早予以强化治疗。
目的：探討老年冠心病患者N耑腦鈉肽前體（NT-proBNP）、脂蛋白（a）[LP（a）]水平與冠狀動脈病變程度之間的關繫。方法入選2011年1月～2012年12月在北京老年醫院心內科住院併行冠狀動脈造影檢查的老年患者213例，根據冠狀動脈造影結果分為非冠心病組（n=60），冠狀動脈單支病變組（n=42），雙支病變組（n=48），三支病變組（n=63）。測定四組患者空腹血清NT-proBNP、LP （a）水平併進行比較，分析NT-proBNP、LP（a）水平與冠心病患者冠狀動脈病變嚴重程度的關繫。結果隨著病變支數的增多，血漿NT-proBNP及LP（a）水平有逐漸增高的趨勢。冠狀動脈單支病變組、雙支病變組和三支病變組患者血漿NT-proBNP及LP（a）水平均高于非冠心病組，差異有統計學意義（P＜0.05）。冠狀動脈單支病變組與三支病變組NT-proBNP及LP（a）水平有統計學差異（P＜0.05），而單支病變組與雙支病變組，雙支病變組與三支病變組間NT-proBNP及LP（a）水平比較無統計學差異（P＞0.05）。Gensini評分與NT-proBNP、LP（a）均呈明顯正相關，相關繫數分彆為0.580、0.406，有顯著統計學意義（P＜0.01）。結論 NT-proBNP、Lp（a）水平與冠狀動脈病變的嚴重程度密切相關，對高NT-proBNP、LP（a）的患者應給予高度重視，儘早予以彊化治療。
목적：탐토노년관심병환자N단뇌납태전체（NT-proBNP）、지단백（a）[LP（a）]수평여관상동맥병변정도지간적관계。방법입선2011년1월～2012년12월재북경노년의원심내과주원병행관상동맥조영검사적노년환자213례，근거관상동맥조영결과분위비관심병조（n=60），관상동맥단지병변조（n=42），쌍지병변조（n=48），삼지병변조（n=63）。측정사조환자공복혈청NT-proBNP、LP （a）수평병진행비교，분석NT-proBNP、LP（a）수평여관심병환자관상동맥병변엄중정도적관계。결과수착병변지수적증다，혈장NT-proBNP급LP（a）수평유축점증고적추세。관상동맥단지병변조、쌍지병변조화삼지병변조환자혈장NT-proBNP급LP（a）수평균고우비관심병조，차이유통계학의의（P＜0.05）。관상동맥단지병변조여삼지병변조NT-proBNP급LP（a）수평유통계학차이（P＜0.05），이단지병변조여쌍지병변조，쌍지병변조여삼지병변조간NT-proBNP급LP（a）수평비교무통계학차이（P＞0.05）。Gensini평분여NT-proBNP、LP（a）균정명현정상관，상관계수분별위0.580、0.406，유현저통계학의의（P＜0.01）。결론 NT-proBNP、Lp（a）수평여관상동맥병변적엄중정도밀절상관，대고NT-proBNP、LP（a）적환자응급여고도중시，진조여이강화치료。
Objective To investigate the correlation between N-terminal pro brain natriuretic peptide (NT-proBNP) or lipoprotein (a) [LP(a)] and severity of coronary artery disease (CAD) in elderly patients with coronary heart disease (CHD). Methods The patients (n=213) were chosen from Jan. 2011 to Dec. 2012, and then divided into non-CHD group (n=60), single-vessel disease group (n=42), 2-vessel disease group (n=48) and 3-vessel disease group (n=63) according to the outcomes of coronary angiography (CAG). The levels of fasting serum NT-proBNP and LP(a) were detected and compared in 4 groups, and the relationship between NT-proBNP or LP(a) and severity of CAD was analyzed. Results The levels of NT-proBNP and LP(a) trended to increase as the diseased vessles increased. The levels of NT-proBNP and LP(a) were higher in single-vessel disease group, 2-vessel disease group and 3-vessel disease group than that in non-CHD group (P<0.05). The difference had statistical significance in the levels of NT-proBNP and LP(a) between single-vessel disease group and 3-vessel disease group (P<0.05), and had no significance between single-vessel disease group and 2-vessel disease group, and between 2-vessel disease group and 3-vessel disease group (P>0.05). The Gensini score was positively correlated to NT-proBNP and LP(a), and correlation coefficient of NT-proBNP was 0.580 and that of LP(a) was 0.406 (P<0.01). Conclusion The levels of NT-proBNP and LP(a) are closely correlated to the severity of CAD. The patients with higher levels of NT-proBNP and LP(a) should be paid high attention to and given intensive treatment as early as possible.
