CAJ | 학술논문

目的：观察机械张力诱发小鼠产生增生性瘢痕的可能性。方法小鼠背部形成2 cm长的手术切口，术后第4天，使用牵拉装置给予创面持续的张力刺激，维持2周后拆除装置，分别在牵引结束后1 d、30 d、60 d观察瘢痕大体形态及组织学形态变化。检测瘢痕面积、细胞数目及胶原量变化情况。结果牵拉后小鼠背部形成类似于人增生性瘢痕组织，并且瘢痕组织可以维持至少60 d，但瘢痕的面积有逐渐减少趋势。结论机械张力诱发的增生性瘢痕动物模型可以形成增生性瘢痕。
목적：관찰궤계장력유발소서산생증생성반흔적가능성。방법소서배부형성2 cm장적수술절구，술후제4천，사용견랍장치급여창면지속적장력자격，유지2주후탁제장치，분별재견인결속후1 d、30 d、60 d관찰반흔대체형태급조직학형태변화。검측반흔면적、세포수목급효원량변화정황。결과견랍후소서배부형성유사우인증생성반흔조직，병차반흔조직가이유지지소60 d，단반흔적면적유축점감소추세。결론궤계장력유발적증생성반흔동물모형가이형성증생성반흔。
Objective To demonstrate whether scars initiated by mechanical load were visually and histopathologically identical to human hypertrophic scars. Methods A 2 cm linear full-thickness incision was made on the dorsum of the mouse. On postoperative day 4, tension on the wounds was created and lasted for 2 weeks. Macroscopic and histological characteristics were examined at day 1, 30, 60 after traction, respectively. The changes of scararea, velative collagen density and cellulartty were cal;culated. Results Resulting scars were structurally identical to human hypertrophic scars and were persisted for more than 60 days. However, area of scars was gradually shrinking. Conclusion Hyperthophic scar in animal model could be initiated by mechanical load.