CAJ | 학술논문

目的：观察帕瑞昔布钠与曲马多超前镇痛在小儿腹腔镜疝修补术后的镇痛效果及不良反应。方法选择择期行小儿腹腔镜疝修补的手术患儿60例，年龄为1～10岁，随机分为三组，帕瑞昔布钠组（P组），曲马多组（T组），和对照组（C组），每组20例。于手术开始前10 min分别注射帕瑞昔布钠1 mg /kg，曲马多1．5 mg /kg，生理盐水2 mL。三组患儿年龄、性别、体重、失血量、手术时间和术中麻醉药用量等无统计学差异。观察拔管后10 min内患儿躁动评分，记录术后0、2、4、8、12 h各时间点疼痛评分及不良反应。结果 P组、T组躁动发生率低于C组，术后各时间点P组疼痛评分显著低于T组与C组，T组恶心呕吐的发生率高于P组与C组，三组患儿无明显呼吸抑制等不良反应。结论帕瑞昔布钠与曲马多超前镇痛在小儿腹腔镜疝修补术中可产生很好的镇痛效果，减少恢复期躁动的发生，帕瑞昔布钠镇痛效果更好，不良反应少。
목적：관찰파서석포납여곡마다초전진통재소인복강경산수보술후적진통효과급불량반응。방법선택택기행소인복강경산수보적수술환인60례，년령위1～10세，수궤분위삼조，파서석포납조（P조），곡마다조（T조），화대조조（C조），매조20례。우수술개시전10 min분별주사파서석포납1 mg /kg，곡마다1．5 mg /kg，생리염수2 mL。삼조환인년령、성별、체중、실혈량、수술시간화술중마취약용량등무통계학차이。관찰발관후10 min내환인조동평분，기록술후0、2、4、8、12 h각시간점동통평분급불량반응。결과 P조、T조조동발생솔저우C조，술후각시간점P조동통평분현저저우T조여C조，T조악심구토적발생솔고우P조여C조，삼조환인무명현호흡억제등불량반응。결론파서석포납여곡마다초전진통재소인복강경산수보술중가산생흔호적진통효과，감소회복기조동적발생，파서석포납진통효과경호，불량반응소。
Objetive To investigate the safety and effectiveness of analgesia used by Parecoxib sodium and tramadol before operation in children undergoing laparoscopic hernia operation. Methods Sixty children undergoing laparoscopic hernia operation were randomly divided into 3 groups.Group P(n=20)undergoing vein administration of Parecoxib sodium 1 mg/kg before operation,group T undergoing vein ad-ministration of tramadol 1 .5 mg/kg before operation,group C undergoing vein administration of 2 mL 0.9% sodium choride.Restlessness score,FLACC score and adverse reactions were ob-served.Results Restlessness score in the group P,the group T were significantly lower than in the group C.At any time after operation,FLACC score in the group P was significantly lower than in the group T,and FLACC score in the group T、the group P was significantly lower than in the group C.The incidence of nausea,vomiting in the group T was higher than in the group P and inthegroupC.ConclusionParecoxibsodiumand tramadoleffectivelyreduced rest-lessnessduringrecovery.Parecoxibsodium showedbettereffectof preemptiveanalgesiain childrenundergoing laparoscopicherniaoperationthan tramadol.