CAJ | 학술논문

人类精子DNA损伤是男性生育力减退的重要原因之一，其可由多种因素诱发精子DNA链断裂或使其双链变性为单链等而形成。具有DNA损伤的精子可在一定程度上逃避体内精子的优化选择机制而将遗传缺陷传递给后代，精子DNA损伤可导致胚胎发育异常、早期流产和先天畸形等相关疾病。文章通过分析评价年龄、禁欲时间、环境、精子冷冻、氧化应激、微量元素以及染色质包装异常等因素对精子DNA损伤，阐述精子DNA损伤的研究现状，为进一步阐明精子DNA损伤的发生机制以及男性不育的预防、治疗和辅助生殖技术选用高质量精子提供基础材料。
인류정자DNA손상시남성생육력감퇴적중요원인지일，기가유다충인소유발정자DNA련단렬혹사기쌍련변성위단련등이형성。구유DNA손상적정자가재일정정도상도피체내정자적우화선택궤제이장유전결함전체급후대，정자DNA손상가도치배태발육이상、조기유산화선천기형등상관질병。문장통과분석평개년령、금욕시간、배경、정자냉동、양화응격、미량원소이급염색질포장이상등인소대정자DNA손상，천술정자DNA손상적연구현상，위진일보천명정자DNA손상적발생궤제이급남성불육적예방、치료화보조생식기술선용고질량정자제공기출재료。
Human sperm DNA damage is one of the common causes of reducing male reproductive capacity. A number of factors can bring out the DNA strand breaks or make double-stranded DNA into single-stranded DNA. To a certain extent, some sperm with damaged DNA may escape from the sperm surveillance mechanism and transmit the damage to the offspring, which may give rise to the associated diseases such as abnormal embryonic development, early natural abortion, congenital anomalies and so on. This review assessses the damage factors of sperm DNA, which include ages, time of celibation, environment, freezing of sperm, oxidative stresse, minor element and the abnormal assembling of chromatin, which provides some basic information for elucidating the mechanism of DNA damage, prevention and treatment of male infertility as well as optimal spermatozoa selection in assisted reproductive technique.