CAJ | 학술논문

青蒿素是从传统中药黄花蒿中分离出来的一种倍半萜类化合物，具有高效的抗疟活性，临床已应用多年，但是由于其溶解性差、生物利用度低及复燃率高等缺点限制了其应用。为改善其以上缺点，人们以双氢青蒿素为母环合成了大量的青蒿素类衍生物，在这些衍生物中有些已在临床上应用多年，有一些的活性还有待评价。对近年来有关青蒿素衍生物的结构修饰新进展进行分类汇总，为其进一步研究提供参考。
청호소시종전통중약황화호중분리출래적일충배반첩류화합물，구유고효적항학활성，림상이응용다년，단시유우기용해성차、생물이용도저급복연솔고등결점한제료기응용。위개선기이상결점，인문이쌍경청호소위모배합성료대량적청호소류연생물，재저사연생물중유사이재림상상응용다년，유일사적활성환유대평개。대근년래유관청호소연생물적결구수식신진전진행분류회총，위기진일보연구제공삼고。
Artemisinin , chemically a sesquiterpene , is isolated from plant Artemisia annua .It has a highly anti-malarial effect and has been used clinically for many years .However , the low solubility , poor bioavail-ability, as well as high recrudescence rate seriously restrict its clinical application .To overcome the disadvan-tages above , many derivatives have been synthesized from dihydroartemisinin , and out of these , the derivatives are either currently in use or being evaluated for use .In this paper , we review the modification of artemisinin derivatives in recent years .This review will provide a reference for further studies .