CAJ | 학술논문

目的：判断刺五加注射液的过敏反应类型，寻找防治刺五加注射液不良反应的途径和方法。方法：豚鼠致敏后，通过测定总IgE、IL-4、IFN-γ水平、嗜酸性粒细胞的数量，同时对各组致敏后豚鼠经抗原激发后的肺组织进行病理切片检查，对刺五加注射液致过敏反应类型进行判断。结果：批号为20100702的刺五加注射液高剂量组可引起致敏豚鼠血清中总IgE、IL-4水平升高、IFN-γ水平降低，批号为20100702的刺五加注射液高剂量组豚鼠肺部出现肺泡壁毛细血管扩张充血，肺泡腔内有少量液体渗出，细支气管腔内有炎性渗出物，其周围可见淋巴细胞浸润等轻微病变；而生理盐水组肺泡壁毛细血管无明显充血，肺泡腔内无液体渗出。结论：某些批号的刺五加注射液可引起实验动物的I型过敏反应。
목적：판단자오가주사액적과민반응류형，심조방치자오가주사액불량반응적도경화방법。방법：돈서치민후，통과측정총IgE、IL-4、IFN-γ수평、기산성립세포적수량，동시대각조치민후돈서경항원격발후적폐조직진행병리절편검사，대자오가주사액치과민반응류형진행판단。결과：비호위20100702적자오가주사액고제량조가인기치민돈서혈청중총IgE、IL-4수평승고、IFN-γ수평강저，비호위20100702적자오가주사액고제량조돈서폐부출현폐포벽모세혈관확장충혈，폐포강내유소량액체삼출，세지기관강내유염성삼출물，기주위가견림파세포침윤등경미병변；이생리염수조폐포벽모세혈관무명현충혈，폐포강내무액체삼출。결론：모사비호적자오가주사액가인기실험동물적I형과민반응。
Objective:To determine the type of allergic reaction of Ciwujia injection , on the basis of founding a method of screening allergens , and to find ways and methods for prevention and treatment of adverse reactions . Methods:Total IgE,IL-4, FN-γlevel and the number of eosinophils were determined after antigen chal-lenge , at the same time in each group of sensitized guinea pigs after antigen challenge , pathological of lung tis-sue was examined , in order to determine the type of allergic reaction of Ciwujia injection .Results: The total IgE, IL-4, FN-γlevel of rats sensitized with No .20100702 of Ciwujia injection in high dose group had a significant difference compared with those in blank group , and Guinea pig lung dilated capillaries in the alveo-lar walls, a small amount of liquid exudation alveolar bronchiole , within the inflammatory exudate , around which there was alymphocytic infiltrate in minimal change; and the saline group had no obvious congestive capillaries in the alveolar walls , alveolar no fluid exudation .Conclusion:I type allergic reaction of the experi-ment animals can be caused by certain batch of Ciwujia injection .