CAJ | 학술논문

采用快速液相-三重串联四极杆质谱（ RRLC-ESI-MS/MS）技术，在电喷雾质谱正模式和负模式下，对红珠胶囊内容物进行分析鉴定。通过质谱中分子离子峰和碎片离子峰的精确相对分子质量匹配，保留时间，紫外光谱对比，与对照品比对并结合参考文献鉴定，确证和指认了红珠胶囊中的新北美圣草苷、樱桃苷、柚皮苷、忍冬苷、野漆树苷、橙皮内酯水合物、7-（2″-α-鼠李糖基-6″-（3″″-羟基-3″″-甲基戊二酰）-β-D-葡萄糖基）柚皮素、异橙皮内酯、柚皮素9个化学成分。研究揭示了红珠胶囊的化学物质基础，为控制该药质量提供了依据。
채용쾌속액상-삼중천련사겁간질보（ RRLC-ESI-MS/MS）기술，재전분무질보정모식화부모식하，대홍주효낭내용물진행분석감정。통과질보중분자리자봉화쇄편리자봉적정학상대분자질량필배，보류시간，자외광보대비，여대조품비대병결합삼고문헌감정，학증화지인료홍주효낭중적신북미골초감、앵도감、유피감、인동감、야칠수감、등피내지수합물、7-（2″-α-서리당기-6″-（3″″-간기-3″″-갑기무이선）-β-D-포도당기）유피소、이등피내지、유피소9개화학성분。연구게시료홍주효낭적화학물질기출，위공제해약질량제공료의거。
RRLC-ESI-MS/MS technique was applied to identify the components of Hongzhu Capsule . ESI-MS/MS analysis was then conducted under both positive and negative modes , matching molecular ion peak , fragment ion peak , retention time and DAD .Nine chemical components , including Neoeriocitrin , Prunin, Naringin, Lonicerin, Rhoifolin, Meranzin hydrate, Meliditin, Isomeranzin, Naringenin were i-dentified .The findings provided the basis for the quality control and pharmacodynamic constituents of Hongzhu capsule .