中华消化病与影像杂志(电子版)
中華消化病與影像雜誌(電子版)
중화소화병여영상잡지(전자판)
2014年
4期
191-194
,共4页
姚杰%刘康%朱伟杰%朱运峰
姚傑%劉康%硃偉傑%硃運峰
요걸%류강%주위걸%주운봉
结直肠肿瘤%基因表达调控%长链非编码RNA%肿瘤标记,生物学
結直腸腫瘤%基因錶達調控%長鏈非編碼RNA%腫瘤標記,生物學
결직장종류%기인표체조공%장련비편마RNA%종류표기,생물학
Colorectal neoplasms%Gene expression regulation%Long non-coding RNA%Tumor markers,biological
长链非编码RNA(lncRNA)在结直肠癌细胞的表观遗传水平、转录水平和转录后水平调控基因的表达,参与肿瘤细胞的凋亡调控、肿瘤浸润与转移等过程中发挥着促癌或抑癌作用,有希望成为结直肠癌诊断及治疗中的新型分子标记物和治疗靶点。
長鏈非編碼RNA(lncRNA)在結直腸癌細胞的錶觀遺傳水平、轉錄水平和轉錄後水平調控基因的錶達,參與腫瘤細胞的凋亡調控、腫瘤浸潤與轉移等過程中髮揮著促癌或抑癌作用,有希望成為結直腸癌診斷及治療中的新型分子標記物和治療靶點。
장련비편마RNA(lncRNA)재결직장암세포적표관유전수평、전록수평화전록후수평조공기인적표체,삼여종류세포적조망조공、종류침윤여전이등과정중발휘착촉암혹억암작용,유희망성위결직장암진단급치료중적신형분자표기물화치료파점。
In colorectal cancer , long non-coding RNA ( lncRNA ) may act as the tumor promoter or tumor suppressor .It regulates gene expression at epigenetic level ,transcriptional level and post-transcriptional level and may be involved in the regulation of multiple cellular biological processes , including apoptosis , tumor invasion and metastasis .lncRNA is hopefully to become the new type of molecular marker and therapeutic target in the diagnosis and treatment of colorectal cancer .