CAJ | 학술논문

间充质干细胞的应用是神经系统疾病治疗的新技术。骨髓、脐血、脂肪源性的间充质干细胞先后被用于治疗癫的实验。在癫治疗中，间充质干细胞主要通过旁分泌细胞因子、神经递质和神经营养因子调节癫病灶的生化环境和受体功能，也可作为基因工程载体发挥治疗作用。本综述总结了间充质干细胞治疗癫的实验方法、移植途径和可能机制。
간충질간세포적응용시신경계통질병치료적신기술。골수、제혈、지방원성적간충질간세포선후피용우치료전적실험。재전치료중，간충질간세포주요통과방분비세포인자、신경체질화신경영양인자조절전병조적생화배경화수체공능，야가작위기인공정재체발휘치료작용。본종술총결료간충질간세포치료전적실험방법、이식도경화가능궤제。
Mesenchymal stem cell (MSC) is a newly developed tool of cell therapy to cure diseases in nervous system. MSCs derived from bone marrow, umbilical cord blood or adipose tissue are mostly used in epilepsy treatment. Through paracrine mechanisms mediated by the release of cytokines, certain neurotransmitters and neurotrophic factors, MSCs contribute to the function of local neurotransmitters and their receptors. By contributing as tools of genetic engineering, MSCs also show a therapeutic activation. In this review, we summarized the basic experiment principles in isolating and culturing MSCs, the ways and mechanics of MSCs transplanted in protecting nervous system from epileptic injury.