CAJ | 학술논문

调节性T细胞是T细胞的一个重要亚型，对维持机体免疫动态平衡具有重要作用。调节性T细胞有两种类型：天然发生的调节性T细胞和诱导产生的调节性T细胞，前者在胸腺中发育；后者由外周幼稚CD4+T细胞衍生而来。调节性T细胞可利用多种机制抑制免疫应答，这些抑制机制可概括为4种基本的“作用模式”：通过抑制性细胞因子发挥抑制作用，通过细胞溶解发挥抑制作用，通过代谢阻断发挥抑制作用，通过调节树突状细胞的成熟或功能发挥抑制作用。文中将天然调节性T细胞和诱导的调节性T细胞的发育以及调节性T细胞的免疫抑制机制做一综述，并简略介绍调节性T细胞在缺血性脑血管病中的作用。
조절성T세포시T세포적일개중요아형，대유지궤체면역동태평형구유중요작용。조절성T세포유량충류형：천연발생적조절성T세포화유도산생적조절성T세포，전자재흉선중발육；후자유외주유치CD4+T세포연생이래。조절성T세포가이용다충궤제억제면역응답，저사억제궤제가개괄위4충기본적“작용모식”：통과억제성세포인자발휘억제작용，통과세포용해발휘억제작용，통과대사조단발휘억제작용，통과조절수돌상세포적성숙혹공능발휘억제작용。문중장천연조절성T세포화유도적조절성T세포적발육이급조절성T세포적면역억제궤제주일종술，병간략개소조절성T세포재결혈성뇌혈관병중적작용。
Regulator T cells (CD4+CD25+Tregs) are a critical subset of T cells that play a fundamental role in maintaining immune homeostasis in vivo. There are two types of Tregs:natural Tregs, which develop in the thymus;induced Tregs, which are derived from naive CD4+T cells in the periphery. Tregs utilize a variety of mechanisms to suppress immune response. The mechanisms can be grouped into four basic modes of action:suppression by inhibitory cytokines, suppression by cytolysis, suppression by metabolic disruption, and suppression by modulation of dendritic-cell (DC) maturation or function. In this review, the development of natural and induced Tregs were discussed, as well as the mechanisms of their utilization in suppression, and the role of Treg cells in ischemic cerebrovascular disease was brielfy induced.