CAJ | 학술논문

目的：分析隐球菌性脑膜炎脑脊液细胞学特点，比较脑脊液细胞学染色、墨汁染色、乳胶凝集实验检出隐球菌的敏感度及特异度，以提高对隐球菌性脑膜炎的认识。方法总结2008年1月至2013年2月确诊的23例隐球菌脑膜炎患者与同期住院的23例非隐球菌脑膜炎患者临床资料及脑脊液细胞学资料并予以分析。结果脑脊液细胞瑞氏吉姆萨染色检测灵敏度91.3%，明显高于墨汁染色灵敏度43.4%，差异有统计学意义(P<0.05)；脑脊液细胞学瑞氏吉姆萨染色检测特异度100%，明显高于乳胶凝集实验法特异度56.5%，差异有统计学意义(P<0.05)。结论脑脊液细胞学检查比传统的墨汁染色法及乳胶凝集实验有更高的灵敏度及特异度，且更直接，是一种先进快捷便利的检测方法。
목적：분석은구균성뇌막염뇌척액세포학특점，비교뇌척액세포학염색、묵즙염색、유효응집실험검출은구균적민감도급특이도，이제고대은구균성뇌막염적인식。방법총결2008년1월지2013년2월학진적23례은구균뇌막염환자여동기주원적23례비은구균뇌막염환자림상자료급뇌척액세포학자료병여이분석。결과뇌척액세포서씨길모살염색검측령민도91.3%，명현고우묵즙염색령민도43.4%，차이유통계학의의(P<0.05)；뇌척액세포학서씨길모살염색검측특이도100%，명현고우유효응집실험법특이도56.5%，차이유통계학의의(P<0.05)。결론뇌척액세포학검사비전통적묵즙염색법급유효응집실험유경고적령민도급특이도，차경직접，시일충선진쾌첩편리적검측방법。
Aim To analyze cryptococcal meningitis cerebrospinal fluid cytology characteristics, compared with cerebrospinal fluid (CSF) cytology, ink staining, cryptococcus latex agglutination test sensitivity and speciifcity, and improve recognization of cryptococcus meningitis. Methods During from January 2008 to February 2013, the clinical records and cerebrospinal lfuid cytological data of 23 patients with cryptococcus meningitis diagnosed in our hospital and that of 23 patients without cryptococcus meningitis in our hospital were analyzed. Results Sensitivity of cerebrospinal lfuid cytology detection was 91.3%, which was signiifcantly higher than that of ink staining detection (43.4%), there was a signiifcant statistical difference (χ2=12.0, P<0.05); Specificity of cerebrospinal fluid cytology detection was 100%, which was signiifcantly higher than that of latex agglutination test method (56.5%), there was a signiifcant statistical difference (χ2=12.79, P<0.05). Conclusion The detection rate of cerebrospinal lfuid cytology examination is more sensitive and speciifc than ink staining and latex agglutination test, which was an quick and convenient detection method.