中国临床神经科学
中國臨床神經科學
중국림상신경과학
CHINESE JOURNAL OF CLINICAL NEUROSCIENCES
2014年
4期
383-388
,共6页
路易体痴呆%123I-FP-CIT单光子发射计算机断层成像%诊断%Meta分析
路易體癡呆%123I-FP-CIT單光子髮射計算機斷層成像%診斷%Meta分析
로역체치태%123I-FP-CIT단광자발사계산궤단층성상%진단%Meta분석
dementia with Lewy bodies%123I-FP-CIT SPECT%diagnosis%Meta-analysis
目的：系统评价123I-FP-CIT单光子发射计算机断层成像(123I-FP-CIT SPECT，DaTSCAN)在路易体痴呆诊断中的价值。方法通过检索PubMed、EMbase、Cochrane、CBM和CNKI数据库相关文献，根据QUADAS评价量表对文献质量进行评价，采用MetaDisc软件对其诊断的敏感度、特异度等进行合并分析和异质性检验。Stata软件Harbord-Egger检验发表偏倚。结果5篇文献符合纳入标准，合并分析结果显示DaTSCAN对路易体痴呆诊断敏感度为0.80(95%CI：0.73~0.86)，特异度为0.93(95%CI：0.89~0.95)，阳性似然比为10.10(95%CI：6.71~15.20)，阴性似然比为0.22(95%CI：0.12~0.39)。合并敏感度经Q异质性假设检验存在显著差异，其他各项合并统计值Q检验无明显异质性。SROC曲线下面积(AUC)为0.9671。Egger线性回归法检验发表偏倚提示纳入Meta分析的文献间无发表偏倚(P=0.089)。结论 DaTSCAN对路易体痴呆诊断具有较高的诊断价值。
目的：繫統評價123I-FP-CIT單光子髮射計算機斷層成像(123I-FP-CIT SPECT，DaTSCAN)在路易體癡呆診斷中的價值。方法通過檢索PubMed、EMbase、Cochrane、CBM和CNKI數據庫相關文獻，根據QUADAS評價量錶對文獻質量進行評價，採用MetaDisc軟件對其診斷的敏感度、特異度等進行閤併分析和異質性檢驗。Stata軟件Harbord-Egger檢驗髮錶偏倚。結果5篇文獻符閤納入標準，閤併分析結果顯示DaTSCAN對路易體癡呆診斷敏感度為0.80(95%CI：0.73~0.86)，特異度為0.93(95%CI：0.89~0.95)，暘性似然比為10.10(95%CI：6.71~15.20)，陰性似然比為0.22(95%CI：0.12~0.39)。閤併敏感度經Q異質性假設檢驗存在顯著差異，其他各項閤併統計值Q檢驗無明顯異質性。SROC麯線下麵積(AUC)為0.9671。Egger線性迴歸法檢驗髮錶偏倚提示納入Meta分析的文獻間無髮錶偏倚(P=0.089)。結論 DaTSCAN對路易體癡呆診斷具有較高的診斷價值。
목적：계통평개123I-FP-CIT단광자발사계산궤단층성상(123I-FP-CIT SPECT，DaTSCAN)재로역체치태진단중적개치。방법통과검색PubMed、EMbase、Cochrane、CBM화CNKI수거고상관문헌，근거QUADAS평개량표대문헌질량진행평개，채용MetaDisc연건대기진단적민감도、특이도등진행합병분석화이질성검험。Stata연건Harbord-Egger검험발표편의。결과5편문헌부합납입표준，합병분석결과현시DaTSCAN대로역체치태진단민감도위0.80(95%CI：0.73~0.86)，특이도위0.93(95%CI：0.89~0.95)，양성사연비위10.10(95%CI：6.71~15.20)，음성사연비위0.22(95%CI：0.12~0.39)。합병민감도경Q이질성가설검험존재현저차이，기타각항합병통계치Q검험무명현이질성。SROC곡선하면적(AUC)위0.9671。Egger선성회귀법검험발표편의제시납입Meta분석적문헌간무발표편의(P=0.089)。결론 DaTSCAN대로역체치태진단구유교고적진단개치。
Aim To systematically value the diagnostic accuracy of 123I-FP-CIT (DaTSCAN) in dementia with Lewy bodies. Methods Relevant literature was searched in the PubMed, Embase, Cochrane, CBM and CNKI databases, and their quality was valued by QUADAS. The diagnostics sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and heterogeneity were pooled by MetaDisc software. Summary receiver-operating characteristic (SROC) curve was constructed. Stata statistical software (version 10.0) was used to assess the publication bias with Harbord-Egger. Results Five literature were included. 123I-FP-CIT (DaTSCAN) could be used to identify dementia with Lewy bodies with overall sensitivity, speciifcity, PLR, NLR, and AUC of 0.80 (95%CI:0.73-0.86),0.93(95%CI:0.89-0.95), 10.10(95%CI: 6.71-15.20), 0.22 (95%CI: 0.12-0.39 ), 0.9671, respectively. There was significant heterogeneity of pooled value of sensitivity, while no signiifcant heterogeneity was observed in other items. Moreover there was no signiifcant publication bias found (P=0.089) accessed with Harbord-Egger indictor test. Conclusion 123I-FP-CIT (DaTSCAN) is valuable for diagnosis in dementia with Lewy bodies.
