CAJ | 학술논문

目的：观察大容量肺灌洗术治疗尘肺患者的临床疗效及其对肿瘤坏死因子-α（ TNF-α）、白细胞介素-6（ IL-6）的影响。方法采用肺灌洗治疗尘肺30例，于治疗前及治疗1周后分别行肺功能检查及TNF-α、IL-6检测，并与26例健康者进行比较。结果大容量灌洗后30例尘肺患者肺功能[用力肺活量（ FVC）、1秒用力呼气量（ FEV1）、最大通气量（MVV）、一氧化碳弥散量（DLCO）]较灌洗前明显改善（P﹤0.05），两组比较差异均有统计学意义（P﹤0.05）。30例尘肺患者灌洗前血清TNF-α、IL-6明显高于灌洗后及健康对照组，两组比较差异均有统计学意义（ P﹤0.05）。结论大容量肺灌洗术治疗对尘肺是安全有效的方法，TNF-α、IL-6可以作为判断尘肺患者病情及疗效的指标。
목적：관찰대용량폐관세술치료진폐환자적림상료효급기대종류배사인자-α（ TNF-α）、백세포개소-6（ IL-6）적영향。방법채용폐관세치료진폐30례，우치료전급치료1주후분별행폐공능검사급TNF-α、IL-6검측，병여26례건강자진행비교。결과대용량관세후30례진폐환자폐공능[용력폐활량（ FVC）、1초용력호기량（ FEV1）、최대통기량（MVV）、일양화탄미산량（DLCO）]교관세전명현개선（P﹤0.05），량조비교차이균유통계학의의（P﹤0.05）。30례진폐환자관세전혈청TNF-α、IL-6명현고우관세후급건강대조조，량조비교차이균유통계학의의（ P﹤0.05）。결론대용량폐관세술치료대진폐시안전유효적방법，TNF-α、IL-6가이작위판단진폐환자병정급료효적지표。
Objective To observe the curative effect of massive whole lung lavage on patients with pneumoconiosis and its effects on tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6). Methods Thirty patient with pneumoconiosis were trea-ted by massive whole lung lavage,before treatment and after one week’s treatment,the pulmonary function and serum TNF-αand IL-6 levels were detected,and were compared with 26 healthy controls. Results Pulmonary function test( FVC,FEV1, MVV,DLCO)of 30 pneumoconiosis patients were significantly improved compared with prior treatment(P﹤0. 05 or P﹤0. 01), The levels of TNF-α and IL-6 of patients with pneumoconiosis before treatment significantly increased compared with those of healthy control group and after treatment(P﹤0. 05 or P﹤0. 01). Conclusion It is safe and effective to use massive whole lung lavage for the pneumoconiosis. TNF-α and IL-6 can be used as the indexes for judgement of the severity and efficacy of patients with pneumoconiosis.