CAJ | 학술논문

目的：探讨急性重症脑出血患者肠黏膜屏障变化。方法选取发病24 h内住院的中、重度脑出血患者40例及健康体检者30例，脑出血组分别于住院后24 h内、3 d、7 d、14 d抽取血清，利用酶联免疫法检测二胺氧化酶（ DAO）、D-乳酸（ D-LAC）的动态变化进行肠黏膜屏障变化的研究。结果脑出血组DAO、D-LAC在发病24 h内迅速升高，并达高峰，持续约2周后呈下降趋势，脑出血组各时间段 DAO、D-LAC 与对照组比较明显升高，差异有统计学意义（ P ﹤0.05）。结论急性重症脑出血患者血清中DAO、D-LAC均增高，提示发病后可出现肠黏膜屏障功能损伤。
목적：탐토급성중증뇌출혈환자장점막병장변화。방법선취발병24 h내주원적중、중도뇌출혈환자40례급건강체검자30례，뇌출혈조분별우주원후24 h내、3 d、7 d、14 d추취혈청，이용매련면역법검측이알양화매（ DAO）、D-유산（ D-LAC）적동태변화진행장점막병장변화적연구。결과뇌출혈조DAO、D-LAC재발병24 h내신속승고，병체고봉，지속약2주후정하강추세，뇌출혈조각시간단 DAO、D-LAC 여대조조비교명현승고，차이유통계학의의（ P ﹤0.05）。결론급성중증뇌출혈환자혈청중DAO、D-LAC균증고，제시발병후가출현장점막병장공능손상。
Objective To study the changes of intestinal mucosal barrier in patients with acute severe cerebral hemorrhage. Methods Forty patients with moderate and severe cerebral hemorrhage admitted within 24 h of onset,and other 30 healthy cases were chose. The dynamic changes of serum diamine oxidase( DAO),D-lactic acid( D-LAC)levels were detected by enzyme linked immunosorbent assay. Results The levels of serum DAO and D-LAC in patients with cerebral hemorrhage rised rapidly within 24 hours of onset,and reached the peak,lasted for 2 weeks,then had the trend of decreasing. The levels of serum DAO and D-LAC in patients with cerebral hemorrhage at different time points were higher than those in the control group,there were significant differences. Conclusion The levels of serum DAO and D-LAC in patients with acute severe cerebral hemorrhage are elevated,indicating that there is injury of intestinal mucosal barrier.