临床麻醉学杂志
臨床痳醉學雜誌
림상마취학잡지
THE JOURNAL OF CLINICAL ANESTHESIOLOGY
2014年
7期
676-678
,共3页
艾司洛尔%丙泊酚%注射痛
艾司洛爾%丙泊酚%註射痛
애사락이%병박분%주사통
Esmolol%Propofol%Injection pain
目的：观察预注小剂量艾司洛尔对丙泊酚注射痛的缓解作用。方法90例在全麻下行乳腺癌根治术患者,随机均分为三组：艾司洛尔组(E 组)、利多卡因组(L 组)和生理盐水组(N 组)。E 组静注艾司洛尔5 mg/ml,2 ml；L 组静注利多卡因20 mg/ml,2 ml；N 组静注2 ml 生理盐水。1 min 后,按照丙泊酚诱导剂量1 mg/kg,先给予1/3剂量,观察三组注射丙泊酚时的疼痛情况,并记录插管前(T1)、插管后即刻(T2)、插管后5 min(T3)BP、HR、SpO2的变化。结果与 N 组比较,E 组和 L 组丙泊酚注射疼痛程度明显下降(P <0.05)。N 组丙泊酚注射痛发生率为25例(83.3%),明显高于 E 组的12例(40.0%)和 L 组的14例(46.7%)(P <0.05),E 组和 L 组丙泊酚注射痛发生率差异无统计学意义。与 T1时比较,T2时 E 组和 L 组 SBP、DBP 和 T2时 N 组 SBP 明显降低(P <0.05),与 T2时比较,T3时 E 组 DBP 明显升高(P <0.05)。结论预注小剂量艾司洛尔可缓解丙泊酚注射痛。
目的：觀察預註小劑量艾司洛爾對丙泊酚註射痛的緩解作用。方法90例在全痳下行乳腺癌根治術患者,隨機均分為三組：艾司洛爾組(E 組)、利多卡因組(L 組)和生理鹽水組(N 組)。E 組靜註艾司洛爾5 mg/ml,2 ml；L 組靜註利多卡因20 mg/ml,2 ml；N 組靜註2 ml 生理鹽水。1 min 後,按照丙泊酚誘導劑量1 mg/kg,先給予1/3劑量,觀察三組註射丙泊酚時的疼痛情況,併記錄插管前(T1)、插管後即刻(T2)、插管後5 min(T3)BP、HR、SpO2的變化。結果與 N 組比較,E 組和 L 組丙泊酚註射疼痛程度明顯下降(P <0.05)。N 組丙泊酚註射痛髮生率為25例(83.3%),明顯高于 E 組的12例(40.0%)和 L 組的14例(46.7%)(P <0.05),E 組和 L 組丙泊酚註射痛髮生率差異無統計學意義。與 T1時比較,T2時 E 組和 L 組 SBP、DBP 和 T2時 N 組 SBP 明顯降低(P <0.05),與 T2時比較,T3時 E 組 DBP 明顯升高(P <0.05)。結論預註小劑量艾司洛爾可緩解丙泊酚註射痛。
목적：관찰예주소제량애사락이대병박분주사통적완해작용。방법90례재전마하행유선암근치술환자,수궤균분위삼조：애사락이조(E 조)、리다잡인조(L 조)화생리염수조(N 조)。E 조정주애사락이5 mg/ml,2 ml；L 조정주리다잡인20 mg/ml,2 ml；N 조정주2 ml 생리염수。1 min 후,안조병박분유도제량1 mg/kg,선급여1/3제량,관찰삼조주사병박분시적동통정황,병기록삽관전(T1)、삽관후즉각(T2)、삽관후5 min(T3)BP、HR、SpO2적변화。결과여 N 조비교,E 조화 L 조병박분주사동통정도명현하강(P <0.05)。N 조병박분주사통발생솔위25례(83.3%),명현고우 E 조적12례(40.0%)화 L 조적14례(46.7%)(P <0.05),E 조화 L 조병박분주사통발생솔차이무통계학의의。여 T1시비교,T2시 E 조화 L 조 SBP、DBP 화 T2시 N 조 SBP 명현강저(P <0.05),여 T2시비교,T3시 E 조 DBP 명현승고(P <0.05)。결론예주소제량애사락이가완해병박분주사통。
Objective To investigate the effect of esmolol pretreatment on propofol injection pain..Methods Ninety patients undergoing breast cancer surgery under general anesthesia were ran-domly assigned into three groups (n=30 each).Group E were pretreated with 5 mg/ml(total 2 ml)es-molol group L with 20 mg/ml (total 2 ml)lidocaine and group N with 2 ml normal saline.After one minute,each group was administrated propofol intravenouly.The pain and hemodynamic data were re-corded.Results Compared with group N,propofol injection pain degree decreased obviously in groups E and L (P <0.05).propofol injection pain occurred in 25 (83.3%)in group N,was signifi-cantly higher than that of 12 (40.0%)in group E and 14 (46.7%)in group L (P <0.05),propofol injection pain had no significant difference between groups E and L.Compared with T1 ,SBP,DBP decreased in groups E and L at T2 ,SBP decreased in group N at T2 significantly (P <0.05).Com-pared with T2 ,DBP was significantly higher at T3 in group E (P <0.05).Conclusion Pretreatment with low dose esmolol was effective in attenuating pain during propofol injection.
