CAJ | 학술논문

目的：评价针药结合治疗抑郁症的临床疗效，探讨其调节Th1/Th2平衡的作用机制。方法：122例抑郁症患者随机分为针药组和对照组各61例。对照组口服氟西汀，针药组在口服氟西汀的基础上配合针刺治疗。4周为一疗程。采用HAMD抑郁量表、SDS抑郁自评量表评价疗效；ELISA法检测两组患者治疗前后血清IFN-γ和IL-4的分泌水平。结果：治疗后两组患者HAMD和SDS量表评分均显著下降（P＜0．05），针药组疗效优于对照组（P＜0．05）；治疗后两组患者IFN-γ水平均显著下降，IL-4水平均显著上升（P＜0．05），针药组与对照组相比有显著性差异（P＜0．05）。结论：在应用抗抑郁药的基础上配合针刺疗效好，其作用机制可能与调节Th1/Th2平衡有关。
목적：평개침약결합치료억욱증적림상료효，탐토기조절Th1/Th2평형적작용궤제。방법：122례억욱증환자수궤분위침약조화대조조각61례。대조조구복불서정，침약조재구복불서정적기출상배합침자치료。4주위일료정。채용HAMD억욱량표、SDS억욱자평량표평개료효；ELISA법검측량조환자치료전후혈청IFN-γ화IL-4적분비수평。결과：치료후량조환자HAMD화SDS량표평분균현저하강（P＜0．05），침약조료효우우대조조（P＜0．05）；치료후량조환자IFN-γ수평균현저하강，IL-4수평균현저상승（P＜0．05），침약조여대조조상비유현저성차이（P＜0．05）。결론：재응용항억욱약적기출상배합침자료효호，기작용궤제가능여조절Th1/Th2평형유관。
Objective:To evaluate the clinical efficacy on depression by acupuncture combined with SSRI anti-depressant , and to discuss its functional mechanism on Th 1/Th2 balance .Methods:122 depressive patients were randomly divided into two groups , acupuncture with antidepressant group and control group .The control group(61 cases) was treated with Fluoxetine Hydrochloride tablets , whereas the acupuncture with antidepres-sant group was treated with acupuncture combined with Fluoxetine Hydrochloride tablets .Four weeks was as a course .HAMD and SDS were used as clinical evaluation scale .The serum secretions of IFN -γand IL-4 were detected by ELISA method .Results:After one course treatment , there was a significant difference between two groups on HAMD and SDS points ( P<0 .05 ) ,and the therapeutic effect was better in the acupuncture with antidepressant group than that in the control group (P<0.05).The secretions of IFN-γin both groups were remarkably lower than pre -treatment ( P<0 .05 ) .The secretions of IL -4 in both groups were remarkably higher than pre-treatment (P<0.05).The difference between two groups on IFN -γand IL-4 after treat-ment was significant ( P <0.05).Conclusion:Acupuncture combined with SSRI antidepressant has a good effect in the clinic , and its functional mechanism may be related to adjusting the balance of Th 1/Th2.