国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
15期
2267-2271
,共5页
宋彪%房思宁%郑利雄%梅忠喜%黄小芳
宋彪%房思寧%鄭利雄%梅忠喜%黃小芳
송표%방사저%정리웅%매충희%황소방
荨麻疹%DNA甲基化%S-腺苷蛋氨酸%S-腺苷同型半胱氨酸
蕁痳疹%DNA甲基化%S-腺苷蛋氨痠%S-腺苷同型半胱氨痠
담마진%DNA갑기화%S-선감단안산%S-선감동형반광안산
Urticaria%DNA methylation%S-adenosylmethionine%S-adenosylhomosysteine
目的 通过检测慢性特发性荨麻疹和自身免疫性荨麻疹的基因组甲基化水平,初步探讨基因组甲基化与其发病机制间的关系.方法 采用ASST方法将45例慢性荨麻疹患者分为慢性特发性荨麻疹组和自身免疫性荨麻疹组.分离血清,分别检测血清中TgAb、TPOAb、ANA、SAM和SAH水平,并对结果进行统计分析.结果 慢性荨麻疹患者ASST阳性率46.7%,对照组ASST全部阴性,两组比较差异有统计学意义(P<0.01).自身免疫荨麻疹组自身抗体检出率最高,TGAb、TPOAb和ANA的阳性率分别是23.80%、14.29%、14.29%;与慢性特发性荨麻疹组及对照组比较,自身免疫荨麻疹组TGAb差异均有统计学意义(P<0.05),TPOAb和ANA的差异均无统计学意义(P>0.05);慢性特发性荨麻疹组与对照组比较,三种自身抗体差异均无统计学意义(P>0.05).自身免疫性荨麻疹组SAM较其它两组低,而SAH高于其它两组,SAM/SAH也较其它两组小,但差异均无统计学意义(P>0.05).慢性特发性荨麻疹组SAM、SAH和SAM/SAH与对照组比较,差异均无统计学意义(P>0.05).结论 我科门诊慢性荨麻疹患者中,自身免疫性荨麻疹所占比例达46.7%;TGAb在自身免疫性荨麻疹患者中阳性率显著高于慢性特发性荨麻疹,能否作为一种有价值的自身免疫性荨麻疹的临床检测指标有待进一步研究;SAM、SAH及其比值在自身免疫性荨麻疹、慢性特发性荨麻疹及对照组中无统计学差异,似乎甲基化并不参与到自身免疫性荨麻疹的发病机制中,但有待更大的样本量证实.
目的 通過檢測慢性特髮性蕁痳疹和自身免疫性蕁痳疹的基因組甲基化水平,初步探討基因組甲基化與其髮病機製間的關繫.方法 採用ASST方法將45例慢性蕁痳疹患者分為慢性特髮性蕁痳疹組和自身免疫性蕁痳疹組.分離血清,分彆檢測血清中TgAb、TPOAb、ANA、SAM和SAH水平,併對結果進行統計分析.結果 慢性蕁痳疹患者ASST暘性率46.7%,對照組ASST全部陰性,兩組比較差異有統計學意義(P<0.01).自身免疫蕁痳疹組自身抗體檢齣率最高,TGAb、TPOAb和ANA的暘性率分彆是23.80%、14.29%、14.29%;與慢性特髮性蕁痳疹組及對照組比較,自身免疫蕁痳疹組TGAb差異均有統計學意義(P<0.05),TPOAb和ANA的差異均無統計學意義(P>0.05);慢性特髮性蕁痳疹組與對照組比較,三種自身抗體差異均無統計學意義(P>0.05).自身免疫性蕁痳疹組SAM較其它兩組低,而SAH高于其它兩組,SAM/SAH也較其它兩組小,但差異均無統計學意義(P>0.05).慢性特髮性蕁痳疹組SAM、SAH和SAM/SAH與對照組比較,差異均無統計學意義(P>0.05).結論 我科門診慢性蕁痳疹患者中,自身免疫性蕁痳疹所佔比例達46.7%;TGAb在自身免疫性蕁痳疹患者中暘性率顯著高于慢性特髮性蕁痳疹,能否作為一種有價值的自身免疫性蕁痳疹的臨床檢測指標有待進一步研究;SAM、SAH及其比值在自身免疫性蕁痳疹、慢性特髮性蕁痳疹及對照組中無統計學差異,似乎甲基化併不參與到自身免疫性蕁痳疹的髮病機製中,但有待更大的樣本量證實.
목적 통과검측만성특발성담마진화자신면역성담마진적기인조갑기화수평,초보탐토기인조갑기화여기발병궤제간적관계.방법 채용ASST방법장45례만성담마진환자분위만성특발성담마진조화자신면역성담마진조.분리혈청,분별검측혈청중TgAb、TPOAb、ANA、SAM화SAH수평,병대결과진행통계분석.결과 만성담마진환자ASST양성솔46.7%,대조조ASST전부음성,량조비교차이유통계학의의(P<0.01).자신면역담마진조자신항체검출솔최고,TGAb、TPOAb화ANA적양성솔분별시23.80%、14.29%、14.29%;여만성특발성담마진조급대조조비교,자신면역담마진조TGAb차이균유통계학의의(P<0.05),TPOAb화ANA적차이균무통계학의의(P>0.05);만성특발성담마진조여대조조비교,삼충자신항체차이균무통계학의의(P>0.05).자신면역성담마진조SAM교기타량조저,이SAH고우기타량조,SAM/SAH야교기타량조소,단차이균무통계학의의(P>0.05).만성특발성담마진조SAM、SAH화SAM/SAH여대조조비교,차이균무통계학의의(P>0.05).결론 아과문진만성담마진환자중,자신면역성담마진소점비례체46.7%;TGAb재자신면역성담마진환자중양성솔현저고우만성특발성담마진,능부작위일충유개치적자신면역성담마진적림상검측지표유대진일보연구;SAM、SAH급기비치재자신면역성담마진、만성특발성담마진급대조조중무통계학차이,사호갑기화병불삼여도자신면역성담마진적발병궤제중,단유대경대적양본량증실.
Objective To explore the association of genome methylation with the pathogenesis of chronic urticaria by detecting genome methylation level of chronic idiopathic urticaria and autoimmune urticaria.Methods 45 patients with chronic urticaria were divided into chronic idiopathic urticaria group and autoimmune urticaria group using ASST method.Serum TgAb,TPOAb,ANA,SAM,and SAH were detected.Results The positive rate of ASST was 46.7% in patients with chronic urticaria,as compared with 0% in control group.There was a statistical significance between the two groups.The positive rates of TgAb,TPOAb,and ANA were 23.80%,14.29%,and 14.29% in autoimmune urticaria group,4.16%,4.16%,and 0 in chronic idiopathic urticaria group,and 5%,0%,and 0% in the control group.TgAb differed significantly between autoimmune urticaria group and the other two groups,but not between chronic idiopathic urticaria group and the control group.TPOAb and ANA did not differ statistically between the two groups.SAM,SAH,and SAM/SAH did not differ significantly.Conclusions Autoimmune urticaria accounts for 46.7% in patients with chronic urticaria.TGAb is significantly higher in autoimmune urticaria patients than in those with chronic idiopathic urticaria.Further research should be done to confirm whether TGAb can be a kind of valuable clinical detection index of autoimmune urticaria.There is no statistical significance in SAM,SAH,and SAM/SAH between the two groups,which is likely to suggest that methylation is not involved in the pathogenesis of autoimmune urticaria.But this conclusion needs to be confirmed by bigger samples.