CAJ | 학술논문

Olig1和Olig2是Olig家族主要成员,近年来研究发现Olig1和Olig2与脱髓鞘疾病、胶质瘤、缺血缺氧性脑损伤等疾病的发生及恢复密切相关,它们不仅参与了少突胶质早期定向分化和晚期成熟分化的转录调控过程,而且对中枢神经系统的正常发育及髓鞘的形成有着至关重要的作用.有关Olig基因与中枢神经系统疾病关系的研究成为国内外研究的热点.
Olig1화Olig2시Olig가족주요성원,근년래연구발현Olig1화Olig2여탈수초질병、효질류、결혈결양성뇌손상등질병적발생급회복밀절상관,타문불부삼여료소돌효질조기정향분화화만기성숙분화적전록조공과정,이차대중추신경계통적정상발육급수초적형성유착지관중요적작용.유관Olig기인여중추신경계통질병관계적연구성위국내외연구적열점.
Oligl and Olig2 are Olig family major members.Recent studies have found that Oligl and Olig2 are closely related to many diseases of central nervous system,such as demyelinating diseases,gliomas and hypoxia-ischemia brain injury.They are not only involved in the directed differentiation of precursor oligodendrocyte and stranscriptional regulation of the maturation of oligodendrocytes,but also play vital roles in the development of the central nervous system and the formation of myelin.Therefore,the research about the relationship of Olig genes and central nervous system diseases have been focused at home and abroad.