CAJ | 학술논문

目的：通过对慢性乙型肝炎患者抗病毒治疗前后进行肝组织病理检查，分析其抗病毒治疗效果。方法收集2005年8月-2012年10月治疗的慢性乙型肝炎29例，在其抗病毒治疗48周前后进行肝穿刺活检检查，比较治疗前后变化。结果与治疗前相比，完全应答组无论炎症或纤维化程度均明显改善（P＜0．01），部分应答组炎症程度得到改善（P＜0．05），纤维化程度则无明显改变（P＞0．05），而无应答组治疗前后相比，炎症及纤维化程度均无明显改变（P＞0．05）。结论无论予干扰素或核苷（酸）类似物抗病毒治疗，获得病毒学完全应答均可明显改善肝脏炎症、纤维化程度。
목적：통과대만성을형간염환자항병독치료전후진행간조직병리검사，분석기항병독치료효과。방법수집2005년8월-2012년10월치료적만성을형간염29례，재기항병독치료48주전후진행간천자활검검사，비교치료전후변화。결과여치료전상비，완전응답조무론염증혹섬유화정도균명현개선（P＜0．01），부분응답조염증정도득도개선（P＜0．05），섬유화정도칙무명현개변（P＞0．05），이무응답조치료전후상비，염증급섬유화정도균무명현개변（P＞0．05）。결론무론여간우소혹핵감（산）유사물항병독치료，획득병독학완전응답균가명현개선간장염증、섬유화정도。
Objective To evaluate the efficacy of antiviral therapy in chronic hepatitis B ( CHB) patients by histologically ex-amination of liver before and after therapy .Methods 29 CHB patients between August 2005 and October 2012 were received biopsy before and after antiviral treatment of 48 weeks,and the histological improvement was evaluated .Results Compared with pretreatment , both inflammation grade and fibrosis stage were significantly improved in complete response group (P<0.01).Through compared with pretreatment,only inflammation grade in part-response group were improved significantly (P<0.05),and fibrosis stage was no obvious change(P>0.05).There was no obvious change of inflammation grade and fibrosis stage in non-response group(P>0.05).Conclu-sion CHB patients treated with interferon or nucleoside analogues ( acid) achieved virological complete response and can greatly im-prove the degree of liver inflammation and fibrosis .