CAJ | 학술논문

目的：对比分析采用抗凝与抗血小板治疗心力衰竭的临床疗效，为临床治疗方案的选择提供参考依据。方法将2008年10月至2012年12月收治的210例慢性心力衰竭患者，按随机数字表法，分为华法林组105例与阿司匹林+波立维组105例，分别进行抗凝治疗与抗血小板治疗，对比2组患者的临床治疗效果。结果随访至2014年1月，华法林组患者的脑栓塞发生率为1.90%，显著低于阿司匹林+波立维组的16.19%，2组对比差异有统计学意义（P<0.05）；华法林组患者的脑出血发生率及治疗有效率分别为7.62%与95.24%，与阿司匹林+波立维组患者的4.76%、92.38%相比，差异无统计学意义（P>0.05）。结论采用抗凝与抗血小板治疗心力衰竭患者，均能取得显著的疗效，但抗凝治疗法更能降低患者脑栓塞发生率，临床上应根据患者的病情及耐受程度，选择最佳的治疗方法，以确保患者的整体治疗质量。
목적：대비분석채용항응여항혈소판치료심력쇠갈적림상료효，위림상치료방안적선택제공삼고의거。방법장2008년10월지2012년12월수치적210례만성심력쇠갈환자，안수궤수자표법，분위화법림조105례여아사필림+파립유조105례，분별진행항응치료여항혈소판치료，대비2조환자적림상치료효과。결과수방지2014년1월，화법림조환자적뇌전새발생솔위1.90%，현저저우아사필림+파립유조적16.19%，2조대비차이유통계학의의（P<0.05）；화법림조환자적뇌출혈발생솔급치료유효솔분별위7.62%여95.24%，여아사필림+파립유조환자적4.76%、92.38%상비，차이무통계학의의（P>0.05）。결론채용항응여항혈소판치료심력쇠갈환자，균능취득현저적료효，단항응치요법경능강저환자뇌전새발생솔，림상상응근거환자적병정급내수정도，선택최가적치료방법，이학보환자적정체치료질량。
Objective To compare the clinical effects of anticoagulation and antiplatelet therapy on heart failure, and to provide reference for the choice of clinical treatment. Methods A total of 210 patients with heart failure who were treated in our hospital from October 2008 to December 2012 were randomly assigned to receive either warfarin for anticoagulation(warfarin group, n=105)or aspirin+plavix for antiplatelet therapy (aspirin+plavix group, n=105). Clinical efficacies were compared between the two groups. Results Patients were followed up to January 2014. The incidence of cerebral embolism in warfarin group was significantly lower than that in aspirin+plavix group (1.90% vs 16.19%, P<0.05). However, no significant differences in the incidence of cerebral hemorrhage and the effective rate of treatment were found between the two groups (7.62%vs 4.76%and 95.24% vs 92.38%, respectively; P>0.05). Conclusion Anticoagulant and antiplatelet therapy can achieve remarkable curative effect on heart failure. However, anticoagulant therapy is superior to antiplatelet therapy for reducing the incidence of cerebral embolism. The optimal treatment should be chosen according to patient’s condition and tolerance to ensure the quality of treatment.