CAJ | 학술논문

目的：探讨内皮脂肪酶（EL）584C/T基因多态性与高血压病（EH）的相关性。方法本研究共纳入160名EH患者和139名对照者。EL 584C/T基因型检测采用聚合酶链反应-限制性内切酶片段多态性（PCR-RFLP）方法检测。结果 EH组CC、CT、TT基因型频率分别为56.3%，42.5%，1.1%；对照组CC、CT、TT基因型频率分别为56.1%，38.8%，5.0%。T等位基因频率在两组间分别为22.5%和24.5%。两组间基因型频率和等位基因频率比较，差异均无统计学意义。Logistic回归显示在矫正传统的EH高危因素后，EL 584C/T多态性仍然与EH之间无相关性。本研究同时表明EL584C/T多态性与血脂之间无明显相关性。结论EL 584C/T基因多态性与常州地区汉族人群EH之间无明显相关性。
목적：탐토내피지방매（EL）584C/T기인다태성여고혈압병（EH）적상관성。방법본연구공납입160명EH환자화139명대조자。EL 584C/T기인형검측채용취합매련반응-한제성내절매편단다태성（PCR-RFLP）방법검측。결과 EH조CC、CT、TT기인형빈솔분별위56.3%，42.5%，1.1%；대조조CC、CT、TT기인형빈솔분별위56.1%，38.8%，5.0%。T등위기인빈솔재량조간분별위22.5%화24.5%。량조간기인형빈솔화등위기인빈솔비교，차이균무통계학의의。Logistic회귀현시재교정전통적EH고위인소후，EL 584C/T다태성잉연여EH지간무상관성。본연구동시표명EL584C/T다태성여혈지지간무명현상관성。결론EL 584C/T기인다태성여상주지구한족인군EH지간무명현상관성。
ObjectiveToinvestigate the association ofendothelial lipase (EL) 584C/T polymorphismwith essential hypertension (EH).Methods The EL 584C/T genotypes were detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)analysisin 160 EH patients and 139 sex- and age-matchedcontrols living in Changzhou region.ResultsThe frequencies of the CC, CT and TT genotypes were respectively 56.3%, 42.5% and 1.1% in EH group,and 56.1%, 38.8% and 5.0% in control group, respectively. The frequency of T allele was 22.5% and 24.5% inEH and control groups, respectively. There was no significant difference between EH and control groups in genotypic and allelic frequencies. Logistic regression analysis showed that there was nosignificantcorrelation between the EL 584C/T gene polymorphism and EH after adjustment oftraditional EH risk factors. There wasno significantcorrelation between EL584C/T genotypesand blood lipids levels.ConclusionThereis no significantcorrelationof EL584C/T polymorphismwithHan nationalityEHpatientsin Changzhou region.