CAJ | 학술논문

目的：探讨血清尿酸水平与老年脑梗死患者复发的关系。方法以2006年1月1日至2008年12月30日期间在山东省4家医院住院的老年急性脑梗死患者1033例为研究对象，采用回顾性分析方法，收集人口统计学、生活方式、疾病史、入院尿酸水平以及脑梗死病史。采用多因素分析方法分析尿酸水平与脑梗死复发的关系。结果复发脑梗死患者尿酸水平明显高于初发脑梗死患者，多因素调整后尿酸水平每升高1个单位，脑梗死患者复发的相对危险性比值比（OR）（95%可信区间CI）为1.002（1.000～1.003），显示尿酸水平升高与脑梗死复发相关联。进一步按尿酸四分位数进行分析，与尿酸最低四分位（＜211μmol/L）水平的脑梗死患者相比，尿酸水平在263～333μmol/L、≥333μmol/L的患者发生不良结局的OR值（95%CI）分别为1.951（1.340～2.839）、1.670（1.140～2.448）。而在211～263μmol/L水平，这种趋势无统计学意义。结论血清尿酸水平升高是脑梗死复发的独立危险因素。
목적：탐토혈청뇨산수평여노년뇌경사환자복발적관계。방법이2006년1월1일지2008년12월30일기간재산동성4가의원주원적노년급성뇌경사환자1033례위연구대상，채용회고성분석방법，수집인구통계학、생활방식、질병사、입원뇨산수평이급뇌경사병사。채용다인소분석방법분석뇨산수평여뇌경사복발적관계。결과복발뇌경사환자뇨산수평명현고우초발뇌경사환자，다인소조정후뇨산수평매승고1개단위，뇌경사환자복발적상대위험성비치비（OR）（95%가신구간CI）위1.002（1.000～1.003），현시뇨산수평승고여뇌경사복발상관련。진일보안뇨산사분위수진행분석，여뇨산최저사분위（＜211μmol/L）수평적뇌경사환자상비，뇨산수평재263～333μmol/L、≥333μmol/L적환자발생불량결국적OR치（95%CI）분별위1.951（1.340～2.839）、1.670（1.140～2.448）。이재211～263μmol/L수평，저충추세무통계학의의。결론혈청뇨산수평승고시뇌경사복발적독립위험인소。
ObjectiveTo investigate thecorrelation betweenthelevel ofserum uric acid(SUA) and recurrent cerebral infarction inelderly patients.MethodsA total of 1033 acute ischemic stroke patientsfrom 4 hospitals in Shangdong Province from January 2006 to December 2008wererecruitedin the study.Data on demographic characteristics,life style,history of disease, SUAat admission andhistory of cerebral infarctionwere collected for all participants.Multi-variate non-conditionedlogisticregression analysiswas used toanalyze the correlation of SUA and recurrent cerebral infarction.Results The SUA 1evel wassignificantly higher in thepatientswith recurrence of cerebral infarction thaninthose with primary cerebral infarction. After adjustment for multivariate, the odds ratio (OD)[95%confidence interval (CI)]of recurrence was 1.002 (1.000-1.003)for every increased unit, indicating the association of SUA andrecurrent cerebral infarction. Logistic analysis wasthenconducted according to quartile of SUA level.The results showed thattheOD(95%CI)of recurrence was 1.951 (1.340-2.839) and 1.670 (1.140-2.448),respectively for the patients withSUA of 263 to333μmol/L and≥333μmol/L, when compared to those with SUA<211μmol/L. But therewas no significant differencein thosewithSUA of 211 to263μmol/L.ConclusionElevated SUAis an independent predictor for the recurrence of cerebral infarction.