浙江中医药大学学报
浙江中醫藥大學學報
절강중의약대학학보
JOURNAL OF ZHEJIANG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
2014年
7期
902-905
,共4页
郑美凤%何芙蓉%林煜芬%郑国尧%郑良朴
鄭美鳳%何芙蓉%林煜芬%鄭國堯%鄭良樸
정미봉%하부용%림욱분%정국요%정량박
原发性失眠%浅针%山根穴%血清褪黑素
原髮性失眠%淺針%山根穴%血清褪黑素
원발성실면%천침%산근혈%혈청퇴흑소
primary insomnia%superficial needling%extra-point Shangen%melatonin
[目的]观察浅针山根穴治疗原发性失眠（PI）患者的临床疗效及其对血清褪黑素（MT）的影响。[方法]36例PI患者为治疗组，运用浅针手法刺激山根穴治疗，采用放射免疫法测定血清MT水平，观察其治疗前后的变化；同时于治疗前、后及治疗结束3个月后评定患者的匹兹堡睡眠质量指数（PSQI）及疗效评价，并对患者治疗前的血清MT与PSQI的相关性进行分析；36例健康人为健康组，不做任何治疗，仅检测血清MT水平以及PSQI评分。[结果]患者治疗后的PSQI总分低于治疗前(P<0.01)，疗程结束3个月后PSQI总分较治疗后升高(P<0.01)，但低于治疗前（P<0.01）；患者治疗后的疗效高于疗程结束3个月后（P<0.01）；患者治疗前的血清MT水平低于健康组（P<0.01），治疗后的血清MT水平高于治疗前（P<0.01），并且接近健康组（P>0.05）；治疗前血清MT水平与PSQI总分、睡眠质量因子分值、睡眠效率因子分值、催眠药物因子分值、日间功能因子分值分别呈负相关关系(P<0.05或P<0.01)。[结论]浅针山根穴治疗PI疗效显著，其作用机制可能与MT水平调节有关。
[目的]觀察淺針山根穴治療原髮性失眠（PI）患者的臨床療效及其對血清褪黑素（MT）的影響。[方法]36例PI患者為治療組，運用淺針手法刺激山根穴治療，採用放射免疫法測定血清MT水平，觀察其治療前後的變化；同時于治療前、後及治療結束3箇月後評定患者的匹玆堡睡眠質量指數（PSQI）及療效評價，併對患者治療前的血清MT與PSQI的相關性進行分析；36例健康人為健康組，不做任何治療，僅檢測血清MT水平以及PSQI評分。[結果]患者治療後的PSQI總分低于治療前(P<0.01)，療程結束3箇月後PSQI總分較治療後升高(P<0.01)，但低于治療前（P<0.01）；患者治療後的療效高于療程結束3箇月後（P<0.01）；患者治療前的血清MT水平低于健康組（P<0.01），治療後的血清MT水平高于治療前（P<0.01），併且接近健康組（P>0.05）；治療前血清MT水平與PSQI總分、睡眠質量因子分值、睡眠效率因子分值、催眠藥物因子分值、日間功能因子分值分彆呈負相關關繫(P<0.05或P<0.01)。[結論]淺針山根穴治療PI療效顯著，其作用機製可能與MT水平調節有關。
[목적]관찰천침산근혈치료원발성실면（PI）환자적림상료효급기대혈청퇴흑소（MT）적영향。[방법]36례PI환자위치료조，운용천침수법자격산근혈치료，채용방사면역법측정혈청MT수평，관찰기치료전후적변화；동시우치료전、후급치료결속3개월후평정환자적필자보수면질량지수（PSQI）급료효평개，병대환자치료전적혈청MT여PSQI적상관성진행분석；36례건강인위건강조，불주임하치료，부검측혈청MT수평이급PSQI평분。[결과]환자치료후적PSQI총분저우치료전(P<0.01)，료정결속3개월후PSQI총분교치료후승고(P<0.01)，단저우치료전（P<0.01）；환자치료후적료효고우료정결속3개월후（P<0.01）；환자치료전적혈청MT수평저우건강조（P<0.01），치료후적혈청MT수평고우치료전（P<0.01），병차접근건강조（P>0.05）；치료전혈청MT수평여PSQI총분、수면질량인자분치、수면효솔인자분치、최면약물인자분치、일간공능인자분치분별정부상관관계(P<0.05혹P<0.01)。[결론]천침산근혈치료PI료효현저，기작용궤제가능여MT수평조절유관。
Objective To observe the clinical curative effect in primary insomnia(PI) with the treatment of superficial needling at Ext-point Shangen and its influence on serum melatonin(MT).[Method] 36 cases of PI patients were clad as treatment group, to use superficial needle at Extra-point Shangen to stimulate the acupuncture point, to use the ria method for determine the serum MT level, to observe the serum MT lever ’s change before and after treatment, and to evaluate the patients’Pittsburgh sleep quality index(PSQI) and curative effect evaluation at the three priods of before and after the treatment and after three months;and 36 cases of normal healthy persons were clad as normal healtihy group, without any treatment, only to determine the serum MT level and evaluate PSQI.[Result] The patients’PSQI score after the treatment was lower than the patients’before treatment(P<0.01), the PSQI score after three months increased(P<0.01), but was also lower than the PSQI score before treatment(P<0.01).The patients’effective rate after the treatment was higher than the patients’after three months(P<0.01). The patients’serum MT level before treatment below the normal healthy group’s(P<0.01); the patients’serum MT level after the treatment was higher than the patients’before treatment(P<0.01), and close to normal healthy group’s(P>0.05).The serum MT level before treatment with the PSQI score, sleep quality factor score, sleep efficiency factor score and hypnotic drug factor score, daytime function factor score were negatively related respectively(P<0.05 or P<0.05).[Conclusion] The clinical curative effect in PI with the treatment of superficial needling at Extra-point Shangen was distinct, and its mechanism may be related to MT level adjustment.
