中国临床新医学
中國臨床新醫學
중국림상신의학
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
2014年
7期
621-624
,共4页
视黄醇结合蛋白%前白蛋白%总胆汁酸%胆碱酯酶%肝脏疾病
視黃醇結閤蛋白%前白蛋白%總膽汁痠%膽堿酯酶%肝髒疾病
시황순결합단백%전백단백%총담즙산%담감지매%간장질병
Retinol binding protein%Prealbumin%Total bile acid%Cholinesterase%Liver disease
目的：探讨视黄醇结合蛋白（RBP）、前白蛋白（PA）、总胆汁酸（TBA）、胆碱酯酶（CHE）在不同类型肝脏疾病中的临床价值。方法应用全自动生化分析仪分别检测110例不同类型肝脏疾病患者RBP、PA、TBA、CHE、丙氨酸氨基转移酶（ ALT）、天冬氨酸氨基转移酶（ AST）水平，观察不同肝病组各项指标的变化，并与68名健康体检者（健康对照组）进行对比分析。结果重症肝炎组、肝硬化组及肝癌组中RBP、PA浓度显著低于健康对照组（ P＜0.01）；五组肝病患者TBA水平显著高于健康对照组（ P＜0.01）；重症肝炎组、肝硬化组及肝癌组中的CHE活力显著低于健康对照组（ P＜0.01）；急性病毒性肝炎组、重症肝炎组ALT、AST活力显著高于健康对照组（ P＜0.01）。结论检测血清RBP、PA、TBA、CHE对肝脏疾病的诊断、治疗和判断预后有一定的临床意义，在反映肝脏实质性病变程度方面优于ALT、AST。 ALT、AST检测同时联合RBP、PA、TBA、CHE检测能更好地反映肝脏功能。
目的：探討視黃醇結閤蛋白（RBP）、前白蛋白（PA）、總膽汁痠（TBA）、膽堿酯酶（CHE）在不同類型肝髒疾病中的臨床價值。方法應用全自動生化分析儀分彆檢測110例不同類型肝髒疾病患者RBP、PA、TBA、CHE、丙氨痠氨基轉移酶（ ALT）、天鼕氨痠氨基轉移酶（ AST）水平，觀察不同肝病組各項指標的變化，併與68名健康體檢者（健康對照組）進行對比分析。結果重癥肝炎組、肝硬化組及肝癌組中RBP、PA濃度顯著低于健康對照組（ P＜0.01）；五組肝病患者TBA水平顯著高于健康對照組（ P＜0.01）；重癥肝炎組、肝硬化組及肝癌組中的CHE活力顯著低于健康對照組（ P＜0.01）；急性病毒性肝炎組、重癥肝炎組ALT、AST活力顯著高于健康對照組（ P＜0.01）。結論檢測血清RBP、PA、TBA、CHE對肝髒疾病的診斷、治療和判斷預後有一定的臨床意義，在反映肝髒實質性病變程度方麵優于ALT、AST。 ALT、AST檢測同時聯閤RBP、PA、TBA、CHE檢測能更好地反映肝髒功能。
목적：탐토시황순결합단백（RBP）、전백단백（PA）、총담즙산（TBA）、담감지매（CHE）재불동류형간장질병중적림상개치。방법응용전자동생화분석의분별검측110례불동류형간장질병환자RBP、PA、TBA、CHE、병안산안기전이매（ ALT）、천동안산안기전이매（ AST）수평，관찰불동간병조각항지표적변화，병여68명건강체검자（건강대조조）진행대비분석。결과중증간염조、간경화조급간암조중RBP、PA농도현저저우건강대조조（ P＜0.01）；오조간병환자TBA수평현저고우건강대조조（ P＜0.01）；중증간염조、간경화조급간암조중적CHE활력현저저우건강대조조（ P＜0.01）；급성병독성간염조、중증간염조ALT、AST활력현저고우건강대조조（ P＜0.01）。결론검측혈청RBP、PA、TBA、CHE대간장질병적진단、치료화판단예후유일정적림상의의，재반영간장실질성병변정도방면우우ALT、AST。 ALT、AST검측동시연합RBP、PA、TBA、CHE검측능경호지반영간장공능。
Objective To study the clinical value of RBP , PA, TBA, CHE in different types of liver dis-ease.Methods The levels of RBP, PA, TBA, CHE, alanine aminotransferase(ALT), aspartate aminotransferase ( AST) in 110 patient with different types of liver disease were detected respectively by automatic biochemistry analy -zer to observe changes in different liver disease groups , and 68 healthy persons ( control group ) were analyzed at the same time.Results The levels of RBP , PA in severe hepatitis group , cirrhosis and liver cancer groups were signifi-cantly lower than that in healthy controls ( P<0.01 ) .The TBA levels in 5 groups of patients with liver disease was significantly higher than that in healthy controls ( P<0.01 ) .But the cholinesterase activity in severe hepatitis , cir-rhosis and liver groups were significantly lower than that in the control group ( P<0.01 ) .The activity of ALT and AST in acute viral hepatitis , severe hepatitis groups were increased significantly .Conclusion It is suggested that de-tecting the levels of RBP, PA, TBA, CHE has some clinical significance for the diagnosis , treatment, and prognosis of liver disease , and is better than of detecting ALT , AST in the reflect the liver substantive lesions .Detection com-bined with RBP , PA, TBA, CHE can better reflect liver function .
