CAJ | 학술논문

右美托咪定是新型高效、高选择性的α2肾上腺素受体激动剂，具有镇痛及剂量依耐性镇静作用，呼吸抑制作用弱，是目前唯一的一种可唤醒的镇静药。但右美托咪定个体差异较大，导致其剂量较难控制，特别表现在特殊人群的应用中。本文对右美托咪定在儿童、老年人以及肝肾功能不全等特殊人群中的药代动力学研究的最新进展进行综述。
우미탁미정시신형고효、고선택성적α2신상선소수체격동제，구유진통급제량의내성진정작용，호흡억제작용약，시목전유일적일충가환성적진정약。단우미탁미정개체차이교대，도치기제량교난공제，특별표현재특수인군적응용중。본문대우미탁미정재인동、노년인이급간신공능불전등특수인군중적약대동역학연구적최신진전진행종술。
Dexmedetomidine , a strong potent and highly selective α2 -adrenoceptor agonist , has an analgesic and dose -dependent sedative property with minimal effects on respiratory depression.It is the only tranquilizing drug which can be arousal currently and is also widely used in clinical applications because of its special pharmacologic characteris-tics.However, dexmedetomidine has large individual differences which made the control of administration dosage more difficult , especially in special populations.So this review article summarized the latest litera-tures about pharmacokinetics of dexmedetomidine in children , the elder-ly , hepatic and renal insufficiency patients and other special populations.