CAJ | 학술논문

目的：观察氟比洛芬酯对家兔定量药物脑电图（ QPEEG ）各频段功率百分比的影响。方法24只成年家兔随机分为4组：0.9％NaCl组和3个剂量（5，10，20 mg· kg-1）氟比洛芬酯组，用QPEEG和功率谱分析法，分析并观察兔耳缘静脉注射氟比洛芬酯前后脑电活动的变化。结果各剂量氟比洛芬酯组对家兔QPEEG各脑区、各频段的功率百分比均无明显影响（ P＞0.05）。结论氟比洛芬酯对家兔QPEEG各频段无明显影响，这与阿片类镇痛药有明显区别。
목적：관찰불비락분지대가토정량약물뇌전도（ QPEEG ）각빈단공솔백분비적영향。방법24지성년가토수궤분위4조：0.9％NaCl조화3개제량（5，10，20 mg· kg-1）불비락분지조，용QPEEG화공솔보분석법，분석병관찰토이연정맥주사불비락분지전후뇌전활동적변화。결과각제량불비락분지조대가토QPEEG각뇌구、각빈단적공솔백분비균무명현영향（ P＞0.05）。결론불비락분지대가토QPEEG각빈단무명현영향，저여아편류진통약유명현구별。
Objective To investigate the effects of flurbiprofen axetil on percentage of each band power of quantitative pharmaco -electroence-hphalography ( QPEEG ) in rabbits.Methods Twenty -four healthy rabbits were randomly divided into four groups ( n =6 ): 0.9%NaCl 1 mL· kg -1 group, flurbiprofen axetil 5, 10, and 20 mg · kg -1 groups.The QPEEG and power spectral analysis were adopted to analyze the changes of brain electrical activities before and after the intravenous in-jection of flurbiprofen axetil.Results Compared with the baseline , the percentages of each encephalic region and band power had no significant differences in these four groups ( P>0.05 ).Conclusion Flurbiprofen axetil has no obvious effect on percentage of each band power of quantita-tive pharmaco-electroencephalography in rabbits , suggesting that its site of action is not in the cerebral cortex.It is quite different from the opioid analgesics.