CAJ | 학술논문

目的：评价替吉奥（ S-1）联合顺铂治疗进展期胃癌的近期疗效及安全性。方法56例进展期胃癌患者分为治疗组和对照组，各28例。治疗组方案为S-160 mg bid，d1～d21；顺铂静脉滴注60 mg· m-2，d1～d3，4周为1个周期。对照组方案为静脉滴注奥沙利铂125 mg · m-2， d1；静脉滴注替加氟600 mg· m-2，d1～d5；静脉滴注亚叶酸钙120 mg· m-2，d1～d5，3周为1个周期。3个周期后评价2组疗效及不良反应。结果治疗组和对照组的客观有效率分别为75.0％和42.9％，差异有统计学意义（ P＜0.05）；治疗组Ⅲ～Ⅳ级不良反应发生率明显低于对照组，差异有统计学意义（ P＜0.05）。结论 S-1联合顺铂化疗方案一线治疗进展期胃癌的近期疗效较好，不良反应可以耐受。
목적：평개체길오（ S-1）연합순박치료진전기위암적근기료효급안전성。방법56례진전기위암환자분위치료조화대조조，각28례。치료조방안위S-160 mg bid，d1～d21；순박정맥적주60 mg· m-2，d1～d3，4주위1개주기。대조조방안위정맥적주오사리박125 mg · m-2， d1；정맥적주체가불600 mg· m-2，d1～d5；정맥적주아협산개120 mg· m-2，d1～d5，3주위1개주기。3개주기후평개2조료효급불량반응。결과치료조화대조조적객관유효솔분별위75.0％화42.9％，차이유통계학의의（ P＜0.05）；치료조Ⅲ～Ⅳ급불량반응발생솔명현저우대조조，차이유통계학의의（ P＜0.05）。결론 S-1연합순박화료방안일선치료진전기위암적근기료효교호，불량반응가이내수。
Objective To evaluate the short-term efficacy and toxicity of the combination of gimeracil and oteracil porassium ( S-1 ) and cispla-tin in the treatment of advanced gastric carcinoma.Methods Fifty-six patients with advanced gastric carcinoma were randomly divided into two groups with 28 cases in each group.Experimental group was treated with S-1 (60 mg bid d1 -d21) combined with cisplatin (60 mg· m-2 iv d1-d3) with 4 weeks as a cycle.While control group was treated with oxaliplatin (130 mg· m-2 iv d1), tegafur (600 mg· m-2 iv d1-d5), calcium folinate ( 120 mg · m-2 iv d1 -d5 ) with 3 weeks as a cycle.Short-term efficacy and adverse reactions were evaluated after three cy-cles.Results The tumor response rate of experimental group and control group was 75.0%and 42.9%(P<0.05).Besides, compared with the con-trol group , the occurrence of gradeⅢ-Ⅳadverse reactions in experimental group were apparently lower.Conclusion The regimen of S -1 combined with cisplatin has shown a better efficacy in the treatment of patients with ad-vanced gastric carcinoma , and the toxicity is relatively mild and tolerable .