CAJ | 학술논문

目的：回顾性分析阿奇霉素联合小儿消积止咳口服液治疗支原体肺炎（ MP）的临床疗效及其对患儿体液免疫功能的影响。方法收治我科肺炎支原体感染患儿87例，其中单纯用阿奇霉素治疗者51例（对照组），用阿奇霉素联合小儿消积止咳口服液治疗者36例（试验组），比较2组患儿临床疗效及其体液免疫功能变化。结果治疗1周后，试验组临床有效率为88.9％，对照组为70.6％，试验组显著高于对照组（ P ＜0.05）。2组患儿的血清免疫球蛋白M （IgM）、免疫球蛋白A（IgA）治疗后较治疗前均显著下降（P＜0.05），但试验组下降更为显著（P＜0.05）。试验组治疗48 h后咳嗽评分显著低于对照组（P＜0.05）。结论阿奇霉素联合小儿消积止咳口服液可显著提高临床疗效，降低患儿体液免疫应答反应。
목적：회고성분석아기매소연합소인소적지해구복액치료지원체폐염（ MP）적림상료효급기대환인체액면역공능적영향。방법수치아과폐염지원체감염환인87례，기중단순용아기매소치료자51례（대조조），용아기매소연합소인소적지해구복액치료자36례（시험조），비교2조환인림상료효급기체액면역공능변화。결과치료1주후，시험조림상유효솔위88.9％，대조조위70.6％，시험조현저고우대조조（ P ＜0.05）。2조환인적혈청면역구단백M （IgM）、면역구단백A（IgA）치료후교치료전균현저하강（P＜0.05），단시험조하강경위현저（P＜0.05）。시험조치료48 h후해수평분현저저우대조조（P＜0.05）。결론아기매소연합소인소적지해구복액가현저제고림상료효，강저환인체액면역응답반응。
Objective To evaluate the clinical efficacy of zithromax combined with Xiaoer Xiaoji Zhike oral liquid in the treatment of myco-plasma pneumonia and their effects on humoral immunity function.Methods Eighty-seven patients with mycoplasma pneumonia were in-cluded in this study.Of the 87 children , 51 were treated with zithromax ( control group ) and others were treated with zithromax combined with Xiaoer Xiaoji Zhike oral liquid ( experiment group ).The clinical efficacy and serum immune index were compared between two groups after treat-ment.Results The clinical efficacy rate of experiment group (88.9%) was much higher than control group ( 70.6%) after one week treatment ( P<0.05 ).After treatment , the serum immunoglobulin M ( IgM ) and immunoglobulin A ( IgA) were significantly decreased in the two groups , with the experiment group decreasing more significantly ( P<0.05 ).The cough scores in the experiment group were significantly lower than that of the control group ( P<0.05 ).Conclusion Zithromax combined with Xiaoer Xiaoji Zhike oral liquid can significantly improve clinical efficacy and reduce the immune response in children .