中国实验诊断学
中國實驗診斷學
중국실험진단학
CHINESE JOURNAL OF LABORATORY DIAGNOSIS
2014年
7期
1145-1148
,共4页
卵巢癌%诊断%CA125%CA199%CEA%检测
卵巢癌%診斷%CA125%CA199%CEA%檢測
란소암%진단%CA125%CA199%CEA%검측
Ovarian cancer%diagnosis%CA125%CA199%CEA
目的：探讨糖类抗原125（CA125）、糖类抗原199（CA199）和癌胚抗原（CEA）联合检测在卵巢癌诊断中的临床意义。方法选择我院收治的卵巢癌患者80例为研究组，卵巢良性疾病患者80例为对照 A 组，来院检查的健康者80例为对照 B 组，采用化学发光法对3组血清中 CA125、CA199和 CEA 含量进行测定。比较3种肿瘤标志物联合检测与单项检测 CA125的诊断意义。结果研究组3种肿瘤标志物水平及阳性率均显著高于对照组，且有显著性差异（P ＜0．05）。两对照组比较无显著性差异（P ＞0．05）。研究组单项检测及联合检测卵巢癌的阳性率均显著高于两对照组（P ＜0．05）。研究组联合检测阳性率为88．75％，明显高于单项检测的73．75％、43．75％和21．25％（P ＜0．05）。CA125、CA199和 CEA 单项检测比较，CA125的敏感性、特异性最佳。CA125的敏感性为73．75％，特异性为90．00％，阳性预测值为78．67％，阴性预测值为87．27％。除特异性外，联合检测的敏感性为88．75％、阳性预测值为79．78％、阴性预测值为94．04％，均较单项检测得以提高，且各指标更加趋于平衡。另外，联合检测对卵巢癌Ⅰ期、Ⅱ期的诊断有效率明显高于单项检测，且有显著性差异（P ＜0．05）。结论CA125、CA199和 CEA 3种肿瘤标志物联合检测能够早期有效地实现对卵巢癌的检测，对于卵巢癌病情的判断、治疗和转归有着重要的意义。
目的：探討糖類抗原125（CA125）、糖類抗原199（CA199）和癌胚抗原（CEA）聯閤檢測在卵巢癌診斷中的臨床意義。方法選擇我院收治的卵巢癌患者80例為研究組，卵巢良性疾病患者80例為對照 A 組，來院檢查的健康者80例為對照 B 組，採用化學髮光法對3組血清中 CA125、CA199和 CEA 含量進行測定。比較3種腫瘤標誌物聯閤檢測與單項檢測 CA125的診斷意義。結果研究組3種腫瘤標誌物水平及暘性率均顯著高于對照組，且有顯著性差異（P ＜0．05）。兩對照組比較無顯著性差異（P ＞0．05）。研究組單項檢測及聯閤檢測卵巢癌的暘性率均顯著高于兩對照組（P ＜0．05）。研究組聯閤檢測暘性率為88．75％，明顯高于單項檢測的73．75％、43．75％和21．25％（P ＜0．05）。CA125、CA199和 CEA 單項檢測比較，CA125的敏感性、特異性最佳。CA125的敏感性為73．75％，特異性為90．00％，暘性預測值為78．67％，陰性預測值為87．27％。除特異性外，聯閤檢測的敏感性為88．75％、暘性預測值為79．78％、陰性預測值為94．04％，均較單項檢測得以提高，且各指標更加趨于平衡。另外，聯閤檢測對卵巢癌Ⅰ期、Ⅱ期的診斷有效率明顯高于單項檢測，且有顯著性差異（P ＜0．05）。結論CA125、CA199和 CEA 3種腫瘤標誌物聯閤檢測能夠早期有效地實現對卵巢癌的檢測，對于卵巢癌病情的判斷、治療和轉歸有著重要的意義。
목적：탐토당류항원125（CA125）、당류항원199（CA199）화암배항원（CEA）연합검측재란소암진단중적림상의의。방법선택아원수치적란소암환자80례위연구조，란소량성질병환자80례위대조 A 조，래원검사적건강자80례위대조 B 조，채용화학발광법대3조혈청중 CA125、CA199화 CEA 함량진행측정。비교3충종류표지물연합검측여단항검측 CA125적진단의의。결과연구조3충종류표지물수평급양성솔균현저고우대조조，차유현저성차이（P ＜0．05）。량대조조비교무현저성차이（P ＞0．05）。연구조단항검측급연합검측란소암적양성솔균현저고우량대조조（P ＜0．05）。연구조연합검측양성솔위88．75％，명현고우단항검측적73．75％、43．75％화21．25％（P ＜0．05）。CA125、CA199화 CEA 단항검측비교，CA125적민감성、특이성최가。CA125적민감성위73．75％，특이성위90．00％，양성예측치위78．67％，음성예측치위87．27％。제특이성외，연합검측적민감성위88．75％、양성예측치위79．78％、음성예측치위94．04％，균교단항검측득이제고，차각지표경가추우평형。령외，연합검측대란소암Ⅰ기、Ⅱ기적진단유효솔명현고우단항검측，차유현저성차이（P ＜0．05）。결론CA125、CA199화 CEA 3충종류표지물연합검측능구조기유효지실현대란소암적검측，대우란소암병정적판단、치료화전귀유착중요적의의。
Objective To investigate clinical significance of the combined detection of carbohydrate antigen 125 (CA125),carbohydrate antigen 199 (CA199)and carcinoembryonic antigen (CEA)in the diagnosis of ovarian cancer. Methods 80 ovarian cancer patients in our hospital were collected as study group,80 cases of benign ovarian diseases (control group A),80 healthy women(control group B).Content of CA125,CA199,CEA were measured by chemilumi-nescence method.Results Levels and positive rates of three kinds of tumor marker of the study group were significant-ly higher than two control groups(P <0.05).There was no significant difference between two control groups (P >0.05).The positive rate of ovarian cancer of study group was significantly higher than two control groups(P <0.05). The positive rate of combined detection was 88.75% was significantly higher than that of single detection,73.75%, 43.75%,21.25% (P <0.05).Comparison of CA125,CA199,CEA single detection,results showed that the sensitivity and specificity of CA125 is the best.The sensitivity of CA125 was 73.75%,the specificity was 90%,the positive pre-dictive value was 78.67%,the negative predictive value was 87.27%.In addition to the specificity,sensitivity of com-bined detection was 88.75%,the positive predictive value was 94.04%,negative predictive value was 79.78%.Com-pared with single detection all index of combined detection can be improved,and each index tends to be more balanced. And the combined detection in the diagnosis of ovarian cancer stage Ⅰ,Ⅱ were significantly higher than single detec-tion (P <0.05).Conclusion Combined detection of CA125,CA199,CEA can effectively realize the detection of early o-varian cancer,has important implications for ovarian cancer,treatment,prognosis judgement.
