CAJ | 학술논문

目的：研究凝血与纤溶系统水平对围术期产妇弥漫性血管内凝血（DIC）的诊断价值。方法选择2007年10月-2012年10月在我院接受治疗的 DIC 产妇40例（DIC 组），选取在我院体检正常的健康孕妇40例（健康孕妇组），同时选取40例健康非孕妇（健康非孕妇组）为研究对象，对三组凝血与纤溶指标进行检测并比较分析。结果健康孕妇组与健康非孕妇组比较显示，PLT、FIB 明显升高，PT、TT、APTT 及 D-D 二聚体水平明显降低，差异有统计学意义（P ＜0．05）；DIC 组与健康孕妇组比较发现，PLT、FIB 明显降低，而 PT、TT 和 APTT 明显延长，D-D 含量明显升高，差异具有统计学意义（P ＜0．05）；DIC 组与健康非孕妇组比较，PLT、FIB 降低，而 PT、APTT 及 D-D 二聚体水平升高，差异有统计学意义（P ＜0．05）。除 APTT 与 PT 之间无关外，DIC 组组内其他的凝血与纤溶指标都具有一定的相互关系（P ＜0．05）。结论凝血与纤溶系统水平对于围术期产妇 DIC 具有重要的诊断意义，APTT、PT 和 TT 水平的升高提示患者凝血功能下降，而 D-D 的升高则说明纤溶的发生。
목적：연구응혈여섬용계통수평대위술기산부미만성혈관내응혈（DIC）적진단개치。방법선택2007년10월-2012년10월재아원접수치료적 DIC 산부40례（DIC 조），선취재아원체검정상적건강잉부40례（건강잉부조），동시선취40례건강비잉부（건강비잉부조）위연구대상，대삼조응혈여섬용지표진행검측병비교분석。결과건강잉부조여건강비잉부조비교현시，PLT、FIB 명현승고，PT、TT、APTT 급 D-D 이취체수평명현강저，차이유통계학의의（P ＜0．05）；DIC 조여건강잉부조비교발현，PLT、FIB 명현강저，이 PT、TT 화 APTT 명현연장，D-D 함량명현승고，차이구유통계학의의（P ＜0．05）；DIC 조여건강비잉부조비교，PLT、FIB 강저，이 PT、APTT 급 D-D 이취체수평승고，차이유통계학의의（P ＜0．05）。제 APTT 여 PT 지간무관외，DIC 조조내기타적응혈여섬용지표도구유일정적상호관계（P ＜0．05）。결론응혈여섬용계통수평대우위술기산부 DIC 구유중요적진단의의，APTT、PT 화 TT 수평적승고제시환자응혈공능하강，이 D-D 적승고칙설명섬용적발생。
Objective To investigate the clinical diagnostic value of coagulation and fibrinolysis system level on peri-operative maternal with DIC.Methods Selected 40 cases of pregnant women with DIC(DIC group)from 2007 October to 2012 October,40 cases of healthy pregnant women(healthy pregnant women group),and 40 cases of healthy non-pregnant women(healthy non-pregnant women group),the blood coagulation and fibrinolysis indexes between three groups were detected and compared.Results Compared with those of the healthy non-pregnant women group,the PLT,FIB of the healthy pregnant women group significantly increased,and PT,TT,APTT and D-D two dimer level significantly reduced,the difference was statistically significant (P <0.05).DIC group compared with healthy pregnant women group showed that PLT and FIB were significantly lower,while PT,TT,APTT,D-D wree higher,the difference was statistically significant (P <0.05).DIC group compared with healthy non-pregnant women group showed that PLT and FIB were significantly lower,while PT,APTT,D-D wree higher,the difference was statistically significant (P <0.05).In addition to no clearance between APTT and PT,DIC group in other blood coagulation and fibrinolysis have certain relations (P <0.05).Conclusion Coagulation and fibrinolysis system level have important diagnostic implica-tions for perioperative maternal with DIC,APTT,PT,TT increased significantly indicating that the coagulation function decreased and D-D increased indicating the fibrinolysis occurs.