CAJ | 학술논문

目的：探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者呼出气冷凝液（EBC）和血清中去甲肾上腺素、瘦素检测的临床意义。方法选择经多导睡眠监测确诊的47例 OSAHS患者（研究组）和40例正常对照者（对照组），采用酶联免疫吸附法测定 EBC和血清中去甲肾上腺素、瘦素水平，47例 OSAHS患者经正压通气治疗3个月后再次进行检测，并比较分析治疗前后去甲肾上腺素、瘦素水平变化情况。结果研究组 EBC和血清中去甲肾上腺素、瘦素水平均显著高于对照组，且均有显著性差异（P＜0．05）。治疗后，研究组 EBC和血清中去甲肾上腺素、瘦素水平较治疗前均明显降低，且均有显著性差异（P＜0．05）。研究组 EBC和血清中去甲肾上腺素和瘦素水平与 AHI呈显著正相关关系，与最低脉氧饱和度（LPSO2）、平均脉氧饱和度（MPSO2）呈显著负相关关系（P＜0．05）。结论 OSAHS患者存在高瘦素血症，且伴有交感神经兴奋性增强，检测去甲肾上腺素、瘦素水平对判断病情严重程度和治疗效果具有重要意义。
목적：탐토조새성수면호흡잠정저통기종합정（OSAHS）환자호출기냉응액（EBC）화혈청중거갑신상선소、수소검측적림상의의。방법선택경다도수면감측학진적47례 OSAHS환자（연구조）화40례정상대조자（대조조），채용매련면역흡부법측정 EBC화혈청중거갑신상선소、수소수평，47례 OSAHS환자경정압통기치료3개월후재차진행검측，병비교분석치료전후거갑신상선소、수소수평변화정황。결과연구조 EBC화혈청중거갑신상선소、수소수평균현저고우대조조，차균유현저성차이（P＜0．05）。치료후，연구조 EBC화혈청중거갑신상선소、수소수평교치료전균명현강저，차균유현저성차이（P＜0．05）。연구조 EBC화혈청중거갑신상선소화수소수평여 AHI정현저정상관관계，여최저맥양포화도（LPSO2）、평균맥양포화도（MPSO2）정현저부상관관계（P＜0．05）。결론 OSAHS환자존재고수소혈증，차반유교감신경흥강성증강，검측거갑신상선소、수소수평대판단병정엄중정도화치료효과구유중요의의。
Objective To investigate clinical significance of NE and leptin level in serum and EBC of patients with OSAHS.Methods 47 patients with OSAHS diagnosed by polysomnography (PSG)(study group)and 40 normal con-trols(control group)were selected.NE and leptin levels were determined by enzyme linked immunosorbent assay.Study group was treated by Continuous positive airway pressure(CPAP),and was determined after 3 months.Results NE and Leptin in serum and EBC of study group were significantly higher than those in the control group(P<0.05).After treatment,NE and Leptin in serum and EBC of study group were significantly lower than before treatment(P<0.05). NE and leptin levels in serum and EBC were positively correlated with AHI,were negatively correlated with LPSO2 , MPSO2 (P<0.05).Conclusion OSAHS patients have high serum leptin,and have enhance of Sympathetic nerve excit-ability.Determination of NE and leptin levels are important in j udging the severity and treatment effect.