CAJ | 학술논문

miRNA由内源性基因转录而来，是一类小分子非编码RNA ，长度约20～24 bp。典型特征是具有发卡结构，转录后具有调控基因表达的功能。有人提出，miRNA在结核病的潜伏感染和活动性感染中扮演着一个重要的控制管理角色，而且miRNA表达量在结核病潜伏性感染和活动性感染患者中具有差异性。更有研究发现miR-155，miR-29a ，miR-361-5p ，miR-889以及miR-576-3p等miRNA在结核分枝杆菌感染者中有一定的表达差异，被人认为可能是结核病的诊断标志。
miRNA유내원성기인전록이래，시일류소분자비편마RNA ，장도약20～24 bp。전형특정시구유발잡결구，전록후구유조공기인표체적공능。유인제출，miRNA재결핵병적잠복감염화활동성감염중분연착일개중요적공제관리각색，이차miRNA표체량재결핵병잠복성감염화활동성감염환자중구유차이성。경유연구발현miR-155，miR-29a ，miR-361-5p ，miR-889이급miR-576-3p등miRNA재결핵분지간균감염자중유일정적표체차이，피인인위가능시결핵병적진단표지。
The miRNA is a class of small molecule non-coding RNA with a length of about 20-24 bp ,which is transcrip-tion from the endogenous gene .The hairpin structure and the post-transcriptional regulation of gene expression are its typical characteristics .It is suggested that the miRNA play an important control and management role in latent infection and active in-fection in tuberculosis ,and the expression situation of miRNA is also different between latent infection and active infection in tuberculosis .Some studies also found that there are differences in the expression of miRNAs such as miR-155 ,miR-29a ,miR-361-5p ,miR-889 ,miR-576-3p and so on ,as a marker of TB diagnose .