CAJ | 학술논문

单核细胞增生性李斯特菌是一种兼性胞内寄生菌，能直接感染抗原递呈细胞，使所运送的外源抗原可以同时进入M HCⅠ类和M HCⅡ类抗原递呈途径，从而诱导强烈的CD＋8 T 细胞和CD＋4 T 细胞免疫应答。目前，减毒李斯特菌作为一种新型的活疫苗载体，在运送宫颈癌、黑色素瘤等肿瘤相关抗原方面业已取得较好的免疫保护效果，在抗肿瘤治疗中显示出诱人的前景。本文综述了单核细胞增生性李斯特菌的免疫应答特性及其作为治疗性肿瘤疫苗载体的相关研究进展。
단핵세포증생성리사특균시일충겸성포내기생균，능직접감염항원체정세포，사소운송적외원항원가이동시진입M HCⅠ류화M HCⅡ류항원체정도경，종이유도강렬적CD＋8 T 세포화CD＋4 T 세포면역응답。목전，감독리사특균작위일충신형적활역묘재체，재운송궁경암、흑색소류등종류상관항원방면업이취득교호적면역보호효과，재항종류치료중현시출유인적전경。본문종술료단핵세포증생성리사특균적면역응답특성급기작위치료성종류역묘재체적상관연구진전。
Listeriamonocytogenes is a facultative intracellular bacterium that enters professional antigen presenting cells , presents passenger antigens to the major histocompatibility complex class I and II pathways ,then elicits CD+4 and CD+8 T-cell-mediated immune responses .It was demonstrated that attenuated Listeriamonocytogenes as a novel live vaccine vector in deliv-ering tumor antigens of cervical cancer and melanoma etc .,could induce strong protective immune response ,and shows effec-tive antitumor immunotherapeutics .This review discussed the characteristics of immune responses elicited by Listeria monocy-togenes ,and the progress of its antitumor immunotherapeutics as delivery vaccine vector .