CAJ | 학술논문

目的：观察复方甘草酸苷治疗寻常型银屑病的临床疗效及药理分析。方法选取2012年～2013年收治的寻常型银屑病患者90例作为研究对象，将患者随机分为观察组及对照组，各45例。两组患者均应用维A酸乳膏、糠酸莫米松乳膏、窄谱中波紫外线治疗，其中观察组患者在此基础上加用复方甘草酸苷静脉滴注，总疗程8周，采用银屑病面积与严重性指数（PASI评分）标准对两组患者的治疗效果进行评价。同时测定患者治疗前后血清IL-17、IL-22、IL-23水平。结果观察组患者临床总有效率明显高于对照组，差异具有统计学意义（P＜0.05）；治疗后血清IL-17、IL-22、IL-23水平明显降低，与治疗前比较差异具有统计学意义（P＜0.05）。结论复方甘草酸苷治疗寻常型银屑病疗效确切，能纠正患者的免疫紊乱状态。
목적：관찰복방감초산감치료심상형은설병적림상료효급약리분석。방법선취2012년～2013년수치적심상형은설병환자90례작위연구대상，장환자수궤분위관찰조급대조조，각45례。량조환자균응용유A산유고、강산막미송유고、착보중파자외선치료，기중관찰조환자재차기출상가용복방감초산감정맥적주，총료정8주，채용은설병면적여엄중성지수（PASI평분）표준대량조환자적치료효과진행평개。동시측정환자치료전후혈청IL-17、IL-22、IL-23수평。결과관찰조환자림상총유효솔명현고우대조조，차이구유통계학의의（P＜0.05）；치료후혈청IL-17、IL-22、IL-23수평명현강저，여치료전비교차이구유통계학의의（P＜0.05）。결론복방감초산감치료심상형은설병료효학절，능규정환자적면역문란상태。
Objective To investigate clinical observation and pharmacological analysis of glycyrrhizin in treating psoriasis vulgaris.Methods 90 cases of patients with psoriasis vulgaris elected as subjects were randomly divided into observation group and control group(45 cases of each group). All patients were treated with vitamin A acid cream, mometasone furoate cream and narrow-band UVB therapy. And the patients of observation group were treated with glycyrrhizin plus by intravenous infusion. After total course of eight weeks, the psoriasis area and the PASI score standards were used to evaluate the treatment of patients of two groups. And serum IL-17, IL-22, IL-23 levels of patients of two groups were determined before and after treatment.Results The total effective rate of observation group was significantly higher than that of control group. The difference was statistically significant(P<0.05). After treatment, serum IL-17, IL-22, IL-23 levels were significantly lower those pre-treatment(P<0.05).Conclusion It reaches a curative treatment for glycyrrhizin in treating psoriasis vulgaris, which correct the patient's immune disorders.