中国处方药
中國處方藥
중국처방약
CHINA PRESCRIPTION DRUG
2014年
7期
30-31
,共2页
复方甘草酸苷%寻常型银屑病%药理分析%临床疗效
複方甘草痠苷%尋常型銀屑病%藥理分析%臨床療效
복방감초산감%심상형은설병%약리분석%림상료효
Glycyrrhizin%Psoriasis%Pharmacological analysis%Clinical efficacy
目的:观察复方甘草酸苷治疗寻常型银屑病的临床疗效及药理分析。方法选取2012年~2013年收治的寻常型银屑病患者90例作为研究对象,将患者随机分为观察组及对照组,各45例。两组患者均应用维A酸乳膏、糠酸莫米松乳膏、窄谱中波紫外线治疗,其中观察组患者在此基础上加用复方甘草酸苷静脉滴注,总疗程8周,采用银屑病面积与严重性指数(PASI评分)标准对两组患者的治疗效果进行评价。同时测定患者治疗前后血清IL-17、IL-22、IL-23水平。结果观察组患者临床总有效率明显高于对照组,差异具有统计学意义(P<0.05);治疗后血清IL-17、IL-22、IL-23水平明显降低,与治疗前比较差异具有统计学意义(P<0.05)。结论复方甘草酸苷治疗寻常型银屑病疗效确切,能纠正患者的免疫紊乱状态。
目的:觀察複方甘草痠苷治療尋常型銀屑病的臨床療效及藥理分析。方法選取2012年~2013年收治的尋常型銀屑病患者90例作為研究對象,將患者隨機分為觀察組及對照組,各45例。兩組患者均應用維A痠乳膏、糠痠莫米鬆乳膏、窄譜中波紫外線治療,其中觀察組患者在此基礎上加用複方甘草痠苷靜脈滴註,總療程8週,採用銀屑病麵積與嚴重性指數(PASI評分)標準對兩組患者的治療效果進行評價。同時測定患者治療前後血清IL-17、IL-22、IL-23水平。結果觀察組患者臨床總有效率明顯高于對照組,差異具有統計學意義(P<0.05);治療後血清IL-17、IL-22、IL-23水平明顯降低,與治療前比較差異具有統計學意義(P<0.05)。結論複方甘草痠苷治療尋常型銀屑病療效確切,能糾正患者的免疫紊亂狀態。
목적:관찰복방감초산감치료심상형은설병적림상료효급약리분석。방법선취2012년~2013년수치적심상형은설병환자90례작위연구대상,장환자수궤분위관찰조급대조조,각45례。량조환자균응용유A산유고、강산막미송유고、착보중파자외선치료,기중관찰조환자재차기출상가용복방감초산감정맥적주,총료정8주,채용은설병면적여엄중성지수(PASI평분)표준대량조환자적치료효과진행평개。동시측정환자치료전후혈청IL-17、IL-22、IL-23수평。결과관찰조환자림상총유효솔명현고우대조조,차이구유통계학의의(P<0.05);치료후혈청IL-17、IL-22、IL-23수평명현강저,여치료전비교차이구유통계학의의(P<0.05)。결론복방감초산감치료심상형은설병료효학절,능규정환자적면역문란상태。
Objective To investigate clinical observation and pharmacological analysis of glycyrrhizin in treating psoriasis vulgaris.Methods 90 cases of patients with psoriasis vulgaris elected as subjects were randomly divided into observation group and control group(45 cases of each group). All patients were treated with vitamin A acid cream, mometasone furoate cream and narrow-band UVB therapy. And the patients of observation group were treated with glycyrrhizin plus by intravenous infusion. After total course of eight weeks, the psoriasis area and the PASI score standards were used to evaluate the treatment of patients of two groups. And serum IL-17, IL-22, IL-23 levels of patients of two groups were determined before and after treatment.Results The total effective rate of observation group was significantly higher than that of control group. The difference was statistically significant(P<0.05). After treatment, serum IL-17, IL-22, IL-23 levels were significantly lower those pre-treatment(P<0.05).Conclusion It reaches a curative treatment for glycyrrhizin in treating psoriasis vulgaris, which correct the patient's immune disorders.