中国医疗设备
中國醫療設備
중국의료설비
CHINA MEDICAL EQUIPMENT
2014年
7期
133-136
,共4页
华琳%夏翃%周萍%安立
華琳%夏翃%週萍%安立
화림%하굉%주평%안립
慢性阻塞性肺疾病%差异表达基因%随机扰动分析%GO功能富集分析%基因芯片
慢性阻塞性肺疾病%差異錶達基因%隨機擾動分析%GO功能富集分析%基因芯片
만성조새성폐질병%차이표체기인%수궤우동분석%GO공능부집분석%기인심편
chronic obstructive pulmonary disease%differentially expressed genes%stochastic disturbance analysis%function enrichment analysis%gene microarray
目的：应用组合策略筛选慢性阻塞性肺疾病（COPD）的差异表达基因。方法采用芯片显著性分析算法（SAM）从GEO数据库中提取COPD差异表达基因，并通过5种基因排序算法对基因进行筛选，并对筛选后的COPD相关基因进行随机扰动分析和GO功能富集分析。结果发现GON4L和P4HB是重要的COPD相关基因。结论组合策略提高了COPD易感基因识别的准确率。
目的：應用組閤策略篩選慢性阻塞性肺疾病（COPD）的差異錶達基因。方法採用芯片顯著性分析算法（SAM）從GEO數據庫中提取COPD差異錶達基因，併通過5種基因排序算法對基因進行篩選，併對篩選後的COPD相關基因進行隨機擾動分析和GO功能富集分析。結果髮現GON4L和P4HB是重要的COPD相關基因。結論組閤策略提高瞭COPD易感基因識彆的準確率。
목적：응용조합책략사선만성조새성폐질병（COPD）적차이표체기인。방법채용심편현저성분석산법（SAM）종GEO수거고중제취COPD차이표체기인，병통과5충기인배서산법대기인진행사선，병대사선후적COPD상관기인진행수궤우동분석화GO공능부집분석。결과발현GON4L화P4HB시중요적COPD상관기인。결론조합책략제고료COPD역감기인식별적준학솔。
Objective To screen differentially expressed genes of chronic obstructive pulmonary disease (COPD) through combined strategy.Methods Significance analysis of microarrays (SAM) was used to extract the differentially expressed genes of COPD from GEO database, which then were screened through five kinds of genetic sort algorithms. Then stochastic disturbance analysis and function enrichment analysis of the screened genes were conducted.Results GON4L and P4HB were important genes related to COPD.Conclusion The recognition accuracy of susceptibility genes of COPD has been improved with the application of combined strategy.
