CAJ | 학술논문

目的：探讨苦参素联合恩替卡韦治疗乙肝后肝硬化的临床效果。方法回顾性分析近一年来80例我院收治的乙肝后肝硬化患者，随机分为A、B两组，每组40人，A组为实验组，B组为对照组。实验组A组苦参素联合恩替卡韦治疗乙肝后肝硬化；对照组B组单纯的西医恩替卡韦用药治疗乙肝后肝硬化。观察两组治疗前后的肝脏基本功能变化以及恢复状况。结果治疗组和对照组患者肝功一般生理功能治疗后疗均有明显恢复，但A组在ALT和AST方面对照组效果更佳明显，不良反应小；对HBeAg影响上，A组、B组两年后HBeAg阴转率分别为85.0%、55.0%；实验组和对照组患者肝功能纤维化血清学指标HA、LN、PCⅢ、CⅣ治疗前后具有明显地不同，A组的治疗效果更佳。结论中西医苦参素与恩替卡韦结合治疗乙肝后肝硬化较单纯的使用西医恩替卡韦的临床效果更明显。
목적：탐토고삼소연합은체잡위치료을간후간경화적림상효과。방법회고성분석근일년래80례아원수치적을간후간경화환자，수궤분위A、B량조，매조40인，A조위실험조，B조위대조조。실험조A조고삼소연합은체잡위치료을간후간경화；대조조B조단순적서의은체잡위용약치료을간후간경화。관찰량조치료전후적간장기본공능변화이급회복상황。결과치료조화대조조환자간공일반생리공능치료후료균유명현회복，단A조재ALT화AST방면대조조효과경가명현，불량반응소；대HBeAg영향상，A조、B조량년후HBeAg음전솔분별위85.0%、55.0%；실험조화대조조환자간공능섬유화혈청학지표HA、LN、PCⅢ、CⅣ치료전후구유명현지불동，A조적치료효과경가。결론중서의고삼소여은체잡위결합치료을간후간경화교단순적사용서의은체잡위적림상효과경명현。
Objective To investigate the clinical effects of the combined treatment of oxymatrine and entecavir for the hepatitis B cirrhosis. Methods 80 patients with hepatitis B cirrhosis in our hospital were randomly selected and divided into two groups, with 40 cases in each group. The experimental group were treated with the combined treatment of oxymatrine and entecavir for the hepatitis B cirrhosis, while the control group received entecavir treatment only. The basic function of the liver and and the recovery status were observed in both groups before and after treatment. Results The general liver function of the experimental group and the control group after treatment were significantly restored. But the ALT and AST of the experimental group were significantly better, with a few adverse reactions. As for the impact on HBeAg, the HBeAg seroconversion rates in the experimental group and the control group were 85%, 55%. The serum markers of liver fibrosis, HA, LN, PCⅢ, CⅣof the experimental group and the control group were significantly different before and after the treatment. The experimental group had better curative efficacy. Conclusions The combined treatment of oxymatrine and entecavir is more effective for the hepatitis B cirrhosis than the entecavir treatment.