CAJ | 학술논문

目的：本研究探讨淋巴瘤患者外周淋巴细胞绝对计数(absolute lymphocyte count,AlC)及CA125检测的临床意义及其与国际预后指数(international prognostic index,IPI)的关系。方法回顾性的分析127例非霍奇金淋巴瘤患者临床资料，对初诊时ALC、CA125、IPI评分系统及疗效进行统计分析。结果中位随访23.1月(7.9~48.3月)总有效率(RR)为73.2%，完全缓解率(CR)为59.8%，总生存率(OS)为55.1%。高ALC(ALC≥1.0×109/L)组和低ALC(ALC<1.0×109/L)组RR率为82.9%和61.4%(P=0.007)，CR率为72.9%和43.9%(P=0.001)，总生存率(OS)为63.2%和30%(P=0.000)。高CA125组和CA125正常组RR率为40%和88.5%(P=0.000)，CR率为20%和78.2%(P=0.000)，总生存率为31%和75%(P=0.000)。将IPI评分0~1分和2分合并为低危组，3分、4~5分合并为高危组，统计分析显示，高危组淋巴细胞绝对计数较低危组明显降低(P=0.020)，高危组CA125水平高于低危组(P=0.000)。结论ALC及CA125可与IPI评分系统一起用于评价弥漫大月细胞淋巴瘤患者的预后。
목적：본연구탐토림파류환자외주림파세포절대계수(absolute lymphocyte count,AlC)급CA125검측적림상의의급기여국제예후지수(international prognostic index,IPI)적관계。방법회고성적분석127례비곽기금림파류환자림상자료，대초진시ALC、CA125、IPI평분계통급료효진행통계분석。결과중위수방23.1월(7.9~48.3월)총유효솔(RR)위73.2%，완전완해솔(CR)위59.8%，총생존솔(OS)위55.1%。고ALC(ALC≥1.0×109/L)조화저ALC(ALC<1.0×109/L)조RR솔위82.9%화61.4%(P=0.007)，CR솔위72.9%화43.9%(P=0.001)，총생존솔(OS)위63.2%화30%(P=0.000)。고CA125조화CA125정상조RR솔위40%화88.5%(P=0.000)，CR솔위20%화78.2%(P=0.000)，총생존솔위31%화75%(P=0.000)。장IPI평분0~1분화2분합병위저위조，3분、4~5분합병위고위조，통계분석현시，고위조림파세포절대계수교저위조명현강저(P=0.020)，고위조CA125수평고우저위조(P=0.000)。결론ALC급CA125가여IPI평분계통일기용우평개미만대월세포림파류환자적예후。
Objective This study aims to investigate the clinical significance and prognostic value of peripheral blood absolute lymphocyte count (ALC) and serum CA125 at patients with non-Hodgkin lymphoma. Methods A totle of 127 patients with non-Hodgkin lymphoma in our department of hematology from 2008-01 to 2013-01 were enrolled and analyzed retrospectively. The correlation between different ALC level and serum CA125 and international prognostic index were statistically analyzed. Results At a median follow-up of 23.1 months, the overall response rate (RR)was 73.2%with 59.8%complete remission rate (CR) and 55.1%overall survival rate (OS). Patients with high ALC (≥1.0í109/L) at diagnosis tended to have higher RR, CR and OS. Patients with low ALC (<1.0í109/L) at diagnosis had bad treatment effect. ALC level in IPI 3~5 groups decreased significantly as compared with those in IPI 0~2 groups (P=0.020). Serum levels of CA125 were significantly elevated in the group IPI score≥2 (P=0.000). Conclusions Our data show that ALC and serum CA125 at diagnosis with IPI scores system can be used for evaluating the prognosis of non-Hodgkin lymphoma patients.