CAJ | 학술논문

目的：通过对类风湿关节炎（ rheumatoid arthritis，RA）和骨关节炎（ osteoarthritis，OA）患者血清及关节液的血管内皮生长因子（ vascular endothelial growth factor，VEGF）的检测，探讨VEGF在两种疾病中的鉴别意义。方法采用酶联免疫吸附试验方法检测RA组（40例）、OA组（40例）血清及关节液中VEGF的含量。结果 RA组血清VEGF含量（94.41±43.32）ng/L，明显高于OA组（35.60±17.08）ng/L，差异有统计学意义（ t=7.987，P<0.001）；RA组关节液VEGF含量（188.26±90.76）ng/L，明显高于OA组（69.72±30.42）ng/L，差异有统计学意义（ t=7.832，P<0.001）；关节液中VEGF和血清中VEGF含量之间存在相关性（r=0.714，P<0.001）。结论 VEGF在RA患者体内高表达，可作为RA与OA鉴别的参考指标。
목적：통과대류풍습관절염（ rheumatoid arthritis，RA）화골관절염（ osteoarthritis，OA）환자혈청급관절액적혈관내피생장인자（ vascular endothelial growth factor，VEGF）적검측，탐토VEGF재량충질병중적감별의의。방법채용매련면역흡부시험방법검측RA조（40례）、OA조（40례）혈청급관절액중VEGF적함량。결과 RA조혈청VEGF함량（94.41±43.32）ng/L，명현고우OA조（35.60±17.08）ng/L，차이유통계학의의（ t=7.987，P<0.001）；RA조관절액VEGF함량（188.26±90.76）ng/L，명현고우OA조（69.72±30.42）ng/L，차이유통계학의의（ t=7.832，P<0.001）；관절액중VEGF화혈청중VEGF함량지간존재상관성（r=0.714，P<0.001）。결론 VEGF재RA환자체내고표체，가작위RA여OA감별적삼고지표。
Objective To detect quantity of vascular endothelial growth factor( VEGF)in synovial fluid and serum of pa-tients with rheumatoid arthritis and osteoarthritis,and explore the clinical significance. Methods Quantity of VEGF in the synovial fluid and serum was determined by ELISA. Results Quantity of VEGF in the serum and synovial fluid in RA cases (94. 41 ± 43. 32 ng/L,188. 26 ± 90. 76 ng/L)were significantly higher than those in OA cases(35. 60 ± 17. 08 ng/L,69. 72 ± 31 ng/L). The content of VEGF in the synovial fluid was higher than that in the serum,and correlation existed between the two indicators(r=0. 714,P<0. 001). Conclusion The content of VEGF of patients with RA is higher than that of patients with OA. The result is expected to provide a new idea for the discrimination of these two diseases.