CAJ | 학술논문

目的：评价波尔多液的亚慢性毒性并研究影响其亚慢性毒性的主要因素。方法通过 SD 大鼠30 d喂养实验,分别以波尔多液和硫酸铜为受试物,观察大鼠生理状况,记录其体重和进食量,并对各组实验动物血液学指标、血液生化学指标以及脏器病理学指标进行了检测。结果各组大鼠生长良好,生理状况正常,各项指标与对照组相比无明显异常。故波尔多液和硫酸铜无明显亚慢性毒性作用,波尔多液的最大无作用剂量超过50 mg/kg BW,作为农药较为安全可靠。结论波尔多液主要成分硫酸铜最大无作用剂量超过125 mg/kg BW,对波尔多液的亚慢性毒性无不良影响。
목적：평개파이다액적아만성독성병연구영향기아만성독성적주요인소。방법통과 SD 대서30 d위양실험,분별이파이다액화류산동위수시물,관찰대서생리상황,기록기체중화진식량,병대각조실험동물혈액학지표、혈액생화학지표이급장기병이학지표진행료검측。결과각조대서생장량호,생리상황정상,각항지표여대조조상비무명현이상。고파이다액화류산동무명현아만성독성작용,파이다액적최대무작용제량초과50 mg/kg BW,작위농약교위안전가고。결론파이다액주요성분류산동최대무작용제량초과125 mg/kg BW,대파이다액적아만성독성무불량영향。
Objective To evaluate the sub-chronic toxicity of bordeaux mixture and study copper sulfate’s impact on bordeaux mixture’s sub-chronic toxicity. Methods SD rats were fed with bordeaux mixture and copper sulfate for 30 d, respectively. The physiological conditions of rats were observed, body weight and food intake were record, and hematological, biochemical parameters and organ pathology were tested. Results Rats grew well, and physiological conditions were normal. The indicators compared with the control group showed no abnormalities. Therefore bordeaux mixture and copper sulfate had no significant sub-chronic toxicity. The observed maximal non-effect dosage of bordeaux mixture was over 50 mg/kg BW and bordeaux mixture was secure as a pesticide. Conclusion The observed maximal non- effect dosage of copper sulfate, the main component of bordeaux mixture is over 125 mg/kg BW and copper sulfate has no adverse effects on bordeaux mixture’s sub-chronic toxicity.