CAJ | 학술논문

纳米金粒子具有独特的物理、化学特性及较好的生物相容性，是目前现有的纳米材料中应用和研究最多的材料之一，其在诸多领域如生物传感器、表面电化学分析、免疫分析、药物传递以及治疗等方面都具有广阔的应用前景。纳米金具有极高的消光系数和强烈的粒子间距效应，其在分散状态下呈红色，变为交联团聚状态后呈蓝色，依据该特性建立了各种各样的纳米金比色快速检测方法。由于纳米金比色法具有操作简便、成本低廉、结果肉眼可见且灵敏度较高等优点，近年来在分析化学尤其是快速检测领域发展迅速，许多影响食品安全的有害物质可通过直接或间接作用影响纳米金的聚合状态，从而使纳米金比色法在食品安全检测中的应用成为可能。本文综述了纳米金比色法的原理及其在食品安全各类污染物中的检测应用，并总结了该方法面临的问题，提出了将来的发展方向。
납미금입자구유독특적물리、화학특성급교호적생물상용성，시목전현유적납미재료중응용화연구최다적재료지일，기재제다영역여생물전감기、표면전화학분석、면역분석、약물전체이급치료등방면도구유엄활적응용전경。납미금구유겁고적소광계수화강렬적입자간거효응，기재분산상태하정홍색，변위교련단취상태후정람색，의거해특성건립료각충각양적납미금비색쾌속검측방법。유우납미금비색법구유조작간편、성본저렴、결과육안가견차령민도교고등우점，근년래재분석화학우기시쾌속검측영역발전신속，허다영향식품안전적유해물질가통과직접혹간접작용영향납미금적취합상태，종이사납미금비색법재식품안전검측중적응용성위가능。본문종술료납미금비색법적원리급기재식품안전각류오염물중적검측응용，병총결료해방법면림적문제，제출료장래적발전방향。
Gold nanoparticle has particular physical and chemical properties as well as good biocompatibil-ity, which has become one of the most applied and studied nanomaterials. It has been widely used in many fields such as electrochemical biosensor, surface chemical analysis, immunoassay, drug delivery, and therapy, etc. Gold nanoparticle has strong size-dependent surface plasmon resonance absorption and can take a color change from red to blue when the dispersed nanoparticles are aggregated. Various biosensing approaches have been designed based on the target which could induce gold nanoparticle solution color changes. Recently gold nanoparticles based colorimetric detection methods developed rapidly especially in rapid detection field with simple operation, low cost, visual results and high sensitivity. Many food chemical contaminants can interact with gold nanoparticles directly or indirectly resulting a color change of gold nanoparticle solution, which make it possible for colorimetric methods based on gold nanoparticles to apply in food safety detection. The recent developments of gold nanoparticle based colorimetric biosensing assays for food safety have been re-viewed and the direction for future research were discussed and proposed.