CAJ | 학술논문

肺癌是世界范围内最常见的恶性肿瘤之一，严重威胁着人类生命健康，其发病的分子机制尚未完全明确，目前已证实 Wnt 通路的异常活化参与肺癌的发生过程。本文就 Wnt 信号在肺癌发生中的作用，Wnt 信号显示其恶性潜能所用到的分子机制，以及在 Wnt 信号通路中能作为药物研发和肺癌治疗靶点的各种节点作一综述。
폐암시세계범위내최상견적악성종류지일，엄중위협착인류생명건강，기발병적분자궤제상미완전명학，목전이증실 Wnt 통로적이상활화삼여폐암적발생과정。본문취 Wnt 신호재폐암발생중적작용，Wnt 신호현시기악성잠능소용도적분자궤제，이급재 Wnt 신호통로중능작위약물연발화폐암치료파점적각충절점작일종술。
Lung cancer is one of the most common cancer throughout the world and is a big threat to human′s health, although it′s mechanism of tumorigenesis is still unclear. Now it has been well known that the abnormal activation of Wnt signaling pathway is associated with lung cancer. In this paper,we made a brief review on the role of Wnt pathway in the de-velopment of lung cancer,the molecular mechanism of Wnt pathway which exhibits its underlying malignancy,and the potent targets in Wnt pathway which can be as the target of the treatment of lung cancer.