CAJ | 학술논문

目的：通过小鼠体外透皮实验，探讨不同促透剂对人参皂苷 rg1体外透皮吸收的影响，确定最佳促透剂，为研制新型透皮吸收制剂奠定基础。方法采用改良 Franz 扩散池法，以离体小鼠皮肤为透皮屏障，以生理盐水为接受介质，加入不同促透剂制备药液样品，以人参皂苷 rg1为定量指标成分进行体外透皮吸收检测，考察人参皂苷 rg1累计透过量。结果无促透剂条件下，人参皂苷 rg1未能透过；单一促透剂中以7%丙二醇效果最好，7%氮酮效果次之，冰片促透作用较小；复合促透剂中，氮酮﹢丙二醇组各浓度下累计透过量接近，氮酮﹢冰片组以两者质量浓度各为2.5%效果较好。结论常用促透剂丙二醇、氮酮、冰片均可增加药物中人参皂苷 rg1的透皮吸收量，其中，7%丙二醇为最佳促透剂。
목적：통과소서체외투피실험，탐토불동촉투제대인삼조감 rg1체외투피흡수적영향，학정최가촉투제，위연제신형투피흡수제제전정기출。방법채용개량 Franz 확산지법，이리체소서피부위투피병장，이생리염수위접수개질，가입불동촉투제제비약액양품，이인삼조감 rg1위정량지표성분진행체외투피흡수검측，고찰인삼조감 rg1루계투과량。결과무촉투제조건하，인삼조감 rg1미능투과；단일촉투제중이7%병이순효과최호，7%담동효과차지，빙편촉투작용교소；복합촉투제중，담동﹢병이순조각농도하루계투과량접근，담동﹢빙편조이량자질량농도각위2.5%효과교호。결론상용촉투제병이순、담동、빙편균가증가약물중인삼조감 rg1적투피흡수량，기중，7%병이순위최가촉투제。
Objective To investigate the effects of different penetration enhancers on transdermal absorption of ginsen-oside rg1 in vitro through skin - penetrating experiments in mice,and determine the best penetration enhancer for laying the foundation for researching new transdermal absorption preparations. Methods Using the modified Franz diffusion pool method,with mice skin as transdermal barrier,physiological saline as accept medium,adding different penetration enhancers to make samples,with ginsenoside rg1 as quantitative indexes for transdermal absorption in vitro tests,measured by high performance liquid chromatography( HPLC) method,inspects the accumulation of ginsenoside rg1 through the vol-ume. Results Without penetration enhancers,ginsenoside rg1 had no accumulation;In single penetration enhancers,7%propylene glycol had the best effect,7% azone came second,borneol in aqueous solution had more lower effect;In compound penetration enhancers,the accumulation of azone ﹢ propylene glycol groups was closing at any concentrations;Effect of azone﹢ borneol group was better when both concentrations were at 2. 5% . Conclusion Common penetration enhancers as azone,propylene glycol and borneol can increase the accumulation of ginsenoside rg1 ,among them,7% propylene glycol was the best.