CAJ | 학술논문

人类基因组中大部分为非编码区，转录产生非编码RNA（ ncRNA）。这些ncRNA可以在表观遗传学水平及转录后水平调控癌基因和抑癌基因的表达，影响肿瘤的发生和发展，是肿瘤诊断、治疗及预后判断的潜在靶标。微小RNA （ miRNA）和长链非编码RNA（ lncRNA）是ncRNA的两个重要分类。其中，lncRNA通过多种机制在不同水平进行基因表达调控，发挥其生物学功能，这些机制包括基因印迹、染色质重塑、细胞周期调控、选择性剪接、mRNA降解和翻译调控等。近年来， miRNA和lncRNA在癌症发生发展中相互作用的分子机制引起了人们的注意。本文主要就这两者在癌症发生发展过程中的相互作用机制及研究方法进行综述。
인류기인조중대부분위비편마구，전록산생비편마RNA（ ncRNA）。저사ncRNA가이재표관유전학수평급전록후수평조공암기인화억암기인적표체，영향종류적발생화발전，시종류진단、치료급예후판단적잠재파표。미소RNA （ miRNA）화장련비편마RNA（ lncRNA）시ncRNA적량개중요분류。기중，lncRNA통과다충궤제재불동수평진행기인표체조공，발휘기생물학공능，저사궤제포괄기인인적、염색질중소、세포주기조공、선택성전접、mRNA강해화번역조공등。근년래， miRNA화lncRNA재암증발생발전중상호작용적분자궤제인기료인문적주의。본문주요취저량자재암증발생발전과정중적상호작용궤제급연구방법진행종술。
Most of the genome are non-coding regions, from which the non-coding RNAs( ncRNA) are transcribed. These ncRNAs may play vital roles in tumorigenesis by regulating oncogene and tumor suppressor gene at either epigenetic level or post-tran-scriptional level, and act as potential targets for tumor diagnosis, prognosis and therapy. MicroRNA(miRNA) and long non-coding RNA( lncRNA) are two important subspecies of ncRNA. LncRNAs play biological roles through a variety of mechanisms, including ge-netic imprinting, chromatin remodeling, cell cycle control, splicing regulation, mRNA decay and translational regulation. Recently, the interaction between miRNA and lncRNA in the development and progression of cancer has drawn the attention of many researchers. This review focuses on the interaction between these two RNAs and its studying methods.